FLT3-IN-41 

FLT3-IN-41 is a highly potent FLT3 inhibitor. The IC₅₀ values of FLT3-IN-41 against human FLT3-ITD and FLT3-WT are 3.16 nM and 294.7 nM, respectively. By binding to the ATP-binding pockets of FLT3-ITD and FLT3-WT and forming hydrogen bonds with hinge region residues and Phe830, FLT3-IN-41 inhibits the STAT5, Akt and Erk signaling pathways. FLT3-IN-41 induces G2/M phase arrest and promotes apoptosis in FLT3-ITD-positive acute myeloid leukemia cells, exhibiting significant antiproliferative activity. FLT3-IN-41 serves as a valuable tool for the study of acute myeloid leukemia^[1].

FLT3-IN-41 (compound 35) (1-100 nM; 24 h) induces G2/M cell cycle arrest in FLT3-ITD-mutated MV4-11 cells in a dose-dependent manner^[1].
FLT3-IN-41 (1-100 nM; 24 h) induces apoptosis in FLT3-ITD-mutated MV4-11 cells in a dose-dependent manner^[1].
FLT3-IN-41 (400 nM; 0-24 h) time-dependently downregulates the mRNA expression levels of STAT5 downstream target genes Osm, Bcl-2, Pim-1 and Cis in FLT3-ITD mutant MV4-11 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

469.45

C₂₆H₁₉N₃O₆

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• [1]. Zhang X, et al. Novel staurosporine-type indolocarbazole glycoalkaloids as potent and selective FLT3-ITD inhibitors for acute myeloid leukemia. Eur J Med Chem. Published online March 13, 2026.