1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
    STAT
  3. BD750

BD750 

Cat. No.: HY-131140
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BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively.

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BD750 Chemical Structure

BD750 Chemical Structure

CAS No. : 892686-59-8

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Description

BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].

IC50 & Target[2]

JAK3

 

STAT5

 

In Vitro

BD750 inhibits human T cell proliferation stimulated either by anti-CD3/anti-CD28 mAbs or by alloantigen in a dose-dependent manner with IC50 values of 1.1 ± 0.2 μM and 1.3 ± 0.2 μM respectively[1].
BD750 also inhibits ConA, PMA/ionomycine or alloantigen-induced mouse T cell proliferation and PHA or PMA/ionomycine-induced human T cell proliferation[1].
BD750 (5 or 20 μM) inhibits the LPS-induced JAK-STAT5 signaling in DC[2].

Western Blot Analysis[2]

Cell Line: Purified immature DCs.
Concentration: 1, 5 or 20 μM.
Incubation Time: 12 h.
Result: Had fewer small dendrites and smaller clusters than typical mDCs (5 or 20 μM).
At a higher dose significantly reduced the levels of LPS-stimulated IL-6, IL-12, TNF-α, IL-1β and IL-23 production by DCs.
In Vivo

BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice[2].

Animal Model: Female C57BL/6 mice (10 wks old, 19-21 g)[2].
Dosage: 20 μM.
Administration: IV, treated DC on d 7, 11 and 15 post the first PTX injection (dpi 7, 11 and 15).
Result: Significantly reduced the frequency of Th1 and Th17 cells and increased the percentage of Tregs compared with mice receiving PBS.
Molecular Weight

271.34

Formula

C₁₄H₁₃N₃OS

CAS No.

892686-59-8

SMILES

OC1=C2CCCCC2=NN1C3=NC4=CC=CC=C4S3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BD750BD 750BD-750JAKSTATJanus kinaseT cellIL2immunosuppressantInhibitorinhibitorinhibit

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BD750
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