892686-59-8
892686-59-8
Chemical Structure
BD750
- CAS No.: 892686-59-8
- Formula:C14H13N3OS
- Molecular Weight:271.34
IUPAC Name: 2-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
InChIKey: QCIFTVIFOWJGTB-UHFFFAOYSA-N
SMILES: OC1=C2CCCCC2=NN1C3=NC4=CC=CC=C4S3
Biological Activity: BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BD750 | 99.70% | BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively. | ||||||||||||||||||||
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References
- [1]. Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43. [Content Brief]
- [2]. Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214. [Content Brief]
