1. PROTAC
    Protein Tyrosine Kinase/RTK
    Apoptosis
  2. PROTAC
    Bcr-Abl
    Apoptosis
  3. GMB-475

GMB-475 

Cat. No.: HY-125834
Handling Instructions

GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.

For research use only. We do not sell to patients.

GMB-475 Chemical Structure

GMB-475 Chemical Structure

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Description

GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].

Molecular Weight

861.93

Formula

C₄₃H₄₆F₃N₇O₇S

SMILES

FC(F)(F)OC1=CC=C(NC2=CC(C3=CC=C(OCCOCC(N[[email protected]](C(C)(C)C)C(N4[[email protected]](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[[email protected]@H](O)C4)=O)=O)C=C3)=NC=N2)C=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GMB-475
Cat. No.:
HY-125834
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