1834571-82-2
Chemical Structure
AC-4-130
- CAS No.: 1834571-82-2
- Formula:C37H36ClF5N2O5S
- Molecular Weight:751.20
IUPAC Name: 4-(2-((N-(4-chlorobenzyl)-2,3,4,5,6-pentafluorophenyl)sulfonamido)-N-(3,5-di-tert-butylbenzyl)acetamido)benzoic acid
InChIKey: NMQUSJQZQWKQBL-UHFFFAOYSA-N
SMILES: FC1=C(C(F)=C(C(F)=C1F)S(=O)(N(CC2=CC=C(C=C2)Cl)CC(N(C3=CC=C(C=C3)C(O)=O)CC4=CC(C(C)(C)C)=CC(C(C)(C)C)=C4)=O)=O)F
Biological Activity: AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)[1].
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AC-4-130 | 99.93% | AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML). | ||||||||||||||||||||
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Keywords
