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Dooku1 

Cat. No.: HY-126010 Purity: >98.0%
Handling Instructions

Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta.

For research use only. We do not sell to patients.

Dooku1 Chemical Structure

Dooku1 Chemical Structure

CAS No. : 2253744-54-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 179 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta[1].

Molecular Weight

326.20

Formula

C₁₃H₉Cl₂N₃OS

CAS No.

2253744-54-4

SMILES

ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (383.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0656 mL 15.3280 mL 30.6560 mL
5 mM 0.6131 mL 3.0656 mL 6.1312 mL
10 mM 0.3066 mL 1.5328 mL 3.0656 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

Dooku1Dooku 1Dooku-1OthersInhibitorinhibitorinhibit

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Product name:
Dooku1
Cat. No.:
HY-126010
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