2253744-54-4
2253744-54-4
Chemical Structure
Dooku1
- CAS No.: 2253744-54-4
- Formula:C13H9Cl2N3OS
- Molecular Weight:326.20
IUPAC Name: 2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
InChIKey: MNPOBXLPCWFONX-UHFFFAOYSA-N
SMILES: ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2
Biological Activity: Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].
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Dooku1 | 99.93% | Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research. | ||||||||||||||||||||
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References
Keywords
