2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK3-IN-1

GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes.

For research use only. We do not sell to patients.

GSK3-IN-1 Chemical Structure

GSK3-IN-1 Chemical Structure

CAS No. : 478482-74-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in DMSO USD 143 In-stock
Solid
5 mg USD 130 In-stock
10 mg USD 220 In-stock
25 mg USD 480 In-stock
50 mg USD 820 In-stock
100 mg USD 1300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

GSK3-IN-1 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes[1].

IC50 & Target

GSK-3[1]
Molecular Weight

303.77

Formula

C14H10ClN3OS
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

ClC1=C(CSC2=NN=C(C3=CC=NC=C3)O2)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (329.20 mM; ultrasonic and warming and heat to 52°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2920 mL 16.4598 mL 32.9196 mL
5 mM 0.6584 mL 3.2920 mL 6.5839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

COA (249 KB) HNMR (247 KB) LCMS (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2920 mL 16.4598 mL 32.9196 mL 82.2991 mL
5 mM 0.6584 mL 3.2920 mL 6.5839 mL 16.4598 mL
10 mM 0.3292 mL 1.6460 mL 3.2920 mL 8.2299 mL
15 mM 0.2195 mL 1.0973 mL 2.1946 mL 5.4866 mL
20 mM 0.1646 mL 0.8230 mL 1.6460 mL 4.1150 mL
25 mM 0.1317 mL 0.6584 mL 1.3168 mL 3.2920 mL
30 mM 0.1097 mL 0.5487 mL 1.0973 mL 2.7433 mL
40 mM 0.0823 mL 0.4115 mL 0.8230 mL 2.0575 mL
50 mM 0.0658 mL 0.3292 mL 0.6584 mL 1.6460 mL
60 mM 0.0549 mL 0.2743 mL 0.5487 mL 1.3717 mL
80 mM 0.0411 mL 0.2057 mL 0.4115 mL 1.0287 mL
100 mM 0.0329 mL 0.1646 mL 0.3292 mL 0.8230 mL
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GSK3-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3-IN-1478482-74-5GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3DiabetesglycogensynthaseInhibitorinhibitorinhibit

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