GSK3β inhibitor II
Based on 1 Customer Validation
GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD).
For research use only. We do not sell to patients.
- Purity: 99.49%
- CAS No.: 478482-75-6
- Formula: C14H10IN3OS
- Molecular Weight:395.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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GSK-3β |
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Cell Line
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Type | Value | Description | References |
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| Fibroblast | IC50 |
625 nM
Compound: 7, GSK3B-II
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Inhibition of human SOD1 expressed in mouse fibroblasts after 48 hrs by ELISA relative to control
Inhibition of human SOD1 expressed in mouse fibroblasts after 48 hrs by ELISA relative to control
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[PMID: 24560539] |
GSK3β inhibitor II shows the hydrophobic interaction with the Ile62, Phe67, Val70, Ala83, and Leu188, ionic inter action with the Lys85, and hydrogen bond interaction with the Lys85 and Val135 residues[1].
GSK3β inhibitor II forms a hydrogen bond with Val135[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 478482-75-6
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Appearance Solid
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Molecular Weight 395.22
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Formula C14H10IN3OS
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Color White to off-white
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SMILES
IC1=CC=CC(CSC(O2)=NN=C2C3=CC=NC=C3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (126.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5302 mL | 12.6512 mL | 25.3024 mL | 63.2559 mL |
| 5 mM | 0.5060 mL | 2.5302 mL | 5.0605 mL | 12.6512 mL | |
| 10 mM | 0.2530 mL | 1.2651 mL | 2.5302 mL | 6.3256 mL | |
| 15 mM | 0.1687 mL | 0.8434 mL | 1.6868 mL | 4.2171 mL | |
| 20 mM | 0.1265 mL | 0.6326 mL | 1.2651 mL | 3.1628 mL | |
| 25 mM | 0.1012 mL | 0.5060 mL | 1.0121 mL | 2.5302 mL | |
| 30 mM | 0.0843 mL | 0.4217 mL | 0.8434 mL | 2.1085 mL | |
| 40 mM | 0.0633 mL | 0.3163 mL | 0.6326 mL | 1.5814 mL | |
| 50 mM | 0.0506 mL | 0.2530 mL | 0.5060 mL | 1.2651 mL | |
| 60 mM | 0.0422 mL | 0.2109 mL | 0.4217 mL | 1.0543 mL | |
| 80 mM | 0.0316 mL | 0.1581 mL | 0.3163 mL | 0.7907 mL | |
| 100 mM | 0.0253 mL | 0.1265 mL | 0.2530 mL | 0.6326 mL |
GSK3β inhibitor II Related Classifications
HY-14679 Related Classifications
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