FAK-IN-10
Based on 1 Customer Validation
FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM,respectively.
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 491839-65-7
- Formula: C15H10BrN3O2S
- Molecular Weight:376.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
780 nM
Compound: 6p
|
Cytotoxicity against human A431 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay
Cytotoxicity against human A431 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay
|
[PMID: 22541051] |
| MCF7 | IC50 |
4230 nM
Compound: 6p
|
Cytotoxicity against human MCF7 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay
|
[PMID: 22541051] |
Chemical Information
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CAS No. 491839-65-7
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Appearance Solid
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Molecular Weight 376.23
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Formula C15H10BrN3O2S
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Color Light yellow to khaki
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SMILES
O=C(CSC1=NN=C(C2=CC=NC=C2)O1)C3=CC=C(C=C3)Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (53.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6579 mL | 13.2897 mL | 26.5795 mL | 66.4487 mL |
| 5 mM | 0.5316 mL | 2.6579 mL | 5.3159 mL | 13.2897 mL | |
| 10 mM | 0.2658 mL | 1.3290 mL | 2.6579 mL | 6.6449 mL | |
| 15 mM | 0.1772 mL | 0.8860 mL | 1.7720 mL | 4.4299 mL | |
| 20 mM | 0.1329 mL | 0.6645 mL | 1.3290 mL | 3.3224 mL | |
| 25 mM | 0.1063 mL | 0.5316 mL | 1.0632 mL | 2.6579 mL | |
| 30 mM | 0.0886 mL | 0.4430 mL | 0.8860 mL | 2.2150 mL | |
| 40 mM | 0.0664 mL | 0.3322 mL | 0.6645 mL | 1.6612 mL | |
| 50 mM | 0.0532 mL | 0.2658 mL | 0.5316 mL | 1.3290 mL |