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Cat. No.: HY-126010R

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Dooku1 (Standard)

Dooku1 (Standard) is the analytical standard of Dooku1 (HY-126010). This product is intended for research and analytical applications. Dooku1 is a reversibly Yoda1 antagonist with IC₅₀ value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca²⁺ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research.

For research use only. We do not sell to patients.

CAS No.: 2253744-54-4
Formula: C₁₃H₉Cl₂N₃OS
Molecular Weight:326.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dooku1 (Standard) Chemical Structure

CAS No.: 2253744-54-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2253744-54-4
Molecular Weight 326.20
Formula C₁₃H₉Cl₂N₃OS
SMILES

ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. [Content Brief]

[2]. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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