1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RF9 hydrochloride

RF9 hydrochloride 

Cat. No.: HY-107382A
Handling Instructions

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

For research use only. We do not sell to patients.

RF9 hydrochloride Chemical Structure

RF9 hydrochloride Chemical Structure

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Other Forms of RF9 hydrochloride:

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Description

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

IC50 & Target[1]

hNPFF1R

58 nM (Ki)

hNPFF2R

75 nM (Ki)

In Vitro

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].

In Vivo

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1].

Animal Model: Rats[1]
Dosage: 0.1 mg/kg.
Administration: S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
Result: Opposed to delaye heroin-induced hyperalgesia and associated tolerance.
Molecular Weight

519.08

Formula

C₂₆H₃₉ClN₆O₃

SMILES

NC(C(CC1=CC=CC=C1)NC([[email protected]](CCCNC(N)=N)NC(C23C[[email protected]](C4)CC(C[[email protected]@H]4C3)C2)=O)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RF9RF 9RF-9Neuropeptide Y ReceptorNPY receptorInhibitorinhibitorinhibit

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RF9 hydrochloride
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HY-107382A
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