1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RF9 hydrochloride

RF9 hydrochloride 

Cat. No.: HY-107382A
Handling Instructions

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

For research use only. We do not sell to patients.

RF9 hydrochloride Chemical Structure

RF9 hydrochloride Chemical Structure

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Other Forms of RF9 hydrochloride:

  • RF9 Get quote
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RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

IC50 & Target[1]


58 nM (Ki)


75 nM (Ki)

In Vitro

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].

In Vivo

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1].

Animal Model: Rats[1]
Dosage: 0.1 mg/kg.
Administration: S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
Result: Opposed to delaye heroin-induced hyperalgesia and associated tolerance.
Molecular Weight





NC(C(CC1=CC=CC=C1)NC([[email protected]](CCCNC(N)=N)NC(C23C[[email protected]](C4)CC(C[[email protected]@H]4C3)C2)=O)=O)=O.Cl


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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