1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RF9 hydrochloride

RF9 hydrochloride 

Cat. No.: HY-107382A
Handling Instructions

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

For research use only. We do not sell to patients.

RF9 hydrochloride Chemical Structure

RF9 hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 975 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of RF9 hydrochloride:

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Description

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

IC50 & Target[1]

hNPFF1R

58 nM (Ki)

hNPFF2R

75 nM (Ki)

In Vitro

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 0.1 mg/kg.
Administration: S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
Result: Opposed to delaye heroin-induced hyperalgesia and associated tolerance.
Molecular Weight

519.08

Formula

C₂₆H₃₉ClN₆O₃

SMILES

NC(C(CC1=CC=CC=C1)NC([[email protected]](CCCNC(N)=N)NC(C23C[[email protected]](C4)CC(C[[email protected]@H]4C3)C2)=O)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (96.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9265 mL 9.6324 mL 19.2649 mL
5 mM 0.3853 mL 1.9265 mL 3.8530 mL
10 mM 0.1926 mL 0.9632 mL 1.9265 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RF9RF 9RF-9Neuropeptide Y ReceptorNPY receptorInhibitorinhibitorinhibit

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Product Name:
RF9 hydrochloride
Cat. No.:
HY-107382A
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