1. GPCR/G Protein
  2. Neuropeptide Y Receptor

Neuropeptide Y (13-36), amide, human (Synonyms: Neuropeptide Y (13-36), human)

Cat. No.: HY-P1480
Handling Instructions

Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neuropeptide Y (13-36), amide, human Chemical Structure

Neuropeptide Y (13-36), amide, human Chemical Structure

CAS No. : 122341-40-6

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.

IC50 & Target

Neuropeptide Y receptor[1]

In Vivo

Intraventricular injections of the Y2 neuropeptide Y receptor agonist porcine Neuropeptide Y (13-36) (25-3000 pM) produces a dose-dependent increase (up to 14%; ED50=0.3 nM for overall effects and 0.97 nM for the peak effects) in mean arterial blood pressure in the awake, unrestrains male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat[1].

References
Animal Administration
[1]

Rats[1]

Neuropeptide Y (13-36) dissolved in 30 μL mock cerebrospinal fluid (CSF), or CSF alone, is injected (30/μL/3 min) by means of an automatic micro-injection pump into the lateral ventricle of freely moving, unrestrained male rats. Five doses of Neuropeptide Y (13-36) (25, 75, 750, 1250, 3000 pM) are injected in order to evaluate possible dose-dependent effects and the effects are compared with the CSF group. A threshold dose of Neuropeptide Y (13-36) is also injected together with a dose of Neuropeptide Y (1-36) (75 pM), close to the ED50 value for its overall vasodepressor action in awake rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

3000.40

Formula

C₁₃₄H₂₀₇N₄₁O₃₆S

CAS No.

122341-40-6

Sequence

Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

Sequence Shortening

PAEDMARYYSALRHYINLITRQRY-NH2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Neuropeptide Y (13-36), amide, human
Cat. No.:
HY-P1480
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Neuropeptide Y (13-36), amide, human

Cat. No.: HY-P1480