2. GPCR/G Protein
    Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 

Cat. No.: HY-P1324 Purity: 99.65%
COA Handling Instructions

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Chemical Structure

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Chemical Structure

CAS No. : 313988-89-5

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1 mg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide:

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Description

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake[1].

IC50 & Target[1]

hY5 receptor

0.24 nM (IC50)

hY1 receptor

530 nM (IC50)

hY2 receptor

>500 nM (IC50)

hY4 receptor

51 nM (IC50)

In Vitro

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide has IC50s of 530 nM, >500 nM, 51 nM for binding to the hY1, hY4, hY2 receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide (0.2, 2 nmol/rat) induces a high amount of food intake in a dose-dependent manner in adult male rats weighing 340-400 g[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

4207.66

Appearance

Solid

Formula

C183H281N57O54S2
CAS No.
Sequence Shortening

GPSQPTYPGDNATPEQMARYYSALRRYINMA{Aib}RQRY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (23.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2377 mL 1.1883 mL 2.3766 mL
5 mM 0.0475 mL 0.2377 mL 0.4753 mL
10 mM 0.0238 mL 0.1188 mL 0.2377 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide313988-89-5Neuropeptide Y ReceptorNPY receptorInhibitorinhibitorinhibit

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