1. GPCR/G Protein Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. SF 11

SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity.

For research use only. We do not sell to patients.

SF 11 Chemical Structure

SF 11 Chemical Structure

CAS No. : 443292-81-7

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 495 In-stock
50 mg USD 840 In-stock
100 mg USD 1300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity[1][2].

IC50 & Target[1]

NPY Y2 receptor

199 nM (IC50)

Molecular Weight

446.60

Formula

C27H30N2O2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(OCC)C=C4)=S)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (559.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2391 mL 11.1957 mL 22.3914 mL
5 mM 0.4478 mL 2.2391 mL 4.4783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2391 mL 11.1957 mL 22.3914 mL 55.9785 mL
5 mM 0.4478 mL 2.2391 mL 4.4783 mL 11.1957 mL
10 mM 0.2239 mL 1.1196 mL 2.2391 mL 5.5979 mL
15 mM 0.1493 mL 0.7464 mL 1.4928 mL 3.7319 mL
20 mM 0.1120 mL 0.5598 mL 1.1196 mL 2.7989 mL
25 mM 0.0896 mL 0.4478 mL 0.8957 mL 2.2391 mL
30 mM 0.0746 mL 0.3732 mL 0.7464 mL 1.8660 mL
40 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3995 mL
50 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1196 mL
60 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9330 mL
80 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6997 mL
100 mM 0.0224 mL 0.1120 mL 0.2239 mL 0.5598 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SF 11
Cat. No.:
HY-107731
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