443292-81-7
443292-81-7
Chemical Structure
SF 11
- CAS No.: 443292-81-7
- Formula:C27H30N2O2S
- Molecular Weight:446.60
IUPAC Name: N-(4-ethoxyphenyl)-4-(hydroxydiphenylmethyl)piperidine-1-carbothioamide
InChIKey: PMEQBGAGFZDWQX-UHFFFAOYSA-N
SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(OCC)C=C4)=S)CC3
Biological Activity: SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity[1][2].
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SF 11 | 98.76% | SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity. | ||||||||||||||||||||
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References
- [1]. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10(8):3454-3463. [Content Brief]
- [2]. Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77(1):46-57. [Content Brief]
