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  4. Allo-aca

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

For research use only. We do not sell to patients.

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CAS No. : 3109368-53-5

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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Allo-aca:

Allo-aca Related Antibodies

Top Publications Citing Use of Products

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2026 Mar 9;44(3):658-675.e12.  [Abstract]

    KMplots and BLI analysis of the mice received chemotherapy along with Veh. or Allo-aca (1 mg/kg; i.p.; every two days) (n = 8 mice/group).

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249.  [Abstract]

    Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Kaplan-Meier survival curve of MLL-AF9 AML mice (n = 5 mice per group).

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249.  [Abstract]

    Representative H&E-stained sections of BM, spleen and liver (scale bars: 20 μm). The results showed that leptin (Allo-aca) (1 mg/kg; i.p.; once daily from days 11 to 20) dampened Ara-C cytotoxicity, extensive leukemic infiltration of liver and spleen.

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249.  [Abstract]

    Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Representative FCM profiles (left) and quantification of YFP+ AML cells in BM, spleen, and liver of MLL-AF9 AML mice (n = 5 mice per group).

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249.  [Abstract]

    Western blot analysis of LEPR expression in AML cells under indicated treatments (Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20), ect.). β-actin served as the loading control.

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249.  [Abstract]

    Effect of Allo-aca on AML cell chemosensitivity by CCK-8 assay. The inhibition rates were calculated from eight treatment arms: (i) PBS; (ii) Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20) alone; (iii) Leptin alone; (iv) Allo-aca + Leptin; (v) Ara-C alone (or DNR); (vi) Allo-aca + Ara-C (or DNR); (vii) Leptin + Ara-C (or DNR) and (viii) Allo-aca + Leptin + Ara-C (or DNR).

    Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249.  [Abstract]

    Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Mitochondrial respiration analysis of sorted MLL-AF9 AML cells using Seahorse XF technology (n = 5 mice per group).

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    • Purity & Documentation

    • References

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    Description

    Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].

    In Vitro

    Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM[1].
    Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca inhibits VEGF mitogenic effects. Allo-aca inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Allo-aca Related Antibodies
    In Vivo

    In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    1074.19

    Formula

    C48H75N13O15
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    {H-allo}-Thr-Glu-{Nva}-Val-Ala-Leu-Ser-Arg-{Aca}-NH2
    Sequence Shortening

    {H-allo}-TE-{Nva}-VALSR-{Aca}-NH2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (46.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (46.55 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9309 mL 4.6547 mL 9.3093 mL
    5 mM 0.1862 mL 0.9309 mL 1.8619 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.82%

    SDS (252 KB)

    COA (249 KB) RP-HPLC (251 KB) MS (70 KB) Elemental Analysis Report (106 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 0.9309 mL 4.6547 mL 9.3093 mL 23.2734 mL
    5 mM 0.1862 mL 0.9309 mL 1.8619 mL 4.6547 mL
    10 mM 0.0931 mL 0.4655 mL 0.9309 mL 2.3273 mL
    15 mM 0.0621 mL 0.3103 mL 0.6206 mL 1.5516 mL
    20 mM 0.0465 mL 0.2327 mL 0.4655 mL 1.1637 mL
    25 mM 0.0372 mL 0.1862 mL 0.3724 mL 0.9309 mL
    30 mM 0.0310 mL 0.1552 mL 0.3103 mL 0.7758 mL
    40 mM 0.0233 mL 0.1164 mL 0.2327 mL 0.5818 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Allo-aca Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Allo-aca3109368-53-5Neuropeptide Y ReceptorOthersNPY receptortriple-negativebreastcancerMDA-MB-231glioblastomaInhibitorinhibitorinhibit

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