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Allo-aca 

Cat. No.: HY-P3212
Handling Instructions

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Allo-aca Chemical Structure

Allo-aca Chemical Structure

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Description

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].

In Vitro

Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM[1].
Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca inhibits VEGF mitogenic effects. Allo-aca inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1074.19

Formula

C₄₈H₇₅N₁₃O₁₅

Sequence Shortening

{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Allo-acaOtherstriple-negativebreastcancerMDA-MB-231glioblastomaInhibitorinhibitorinhibit

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Allo-aca
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