2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M871

M871  (Synonyms: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide)

Cat. No.: HY-P1130 Purity: 98.69%
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M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM and 420 nM for GalR2 and GalR1, respectively. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

M871 Chemical Structure

M871 Chemical Structure

CAS No. : 908844-75-7

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1 mg USD 150 In-stock
5 mg USD 375 In-stock
10 mg USD 580 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM and 420 nM for GalR2 and GalR1, respectively. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain)[1].

IC50 & Target

GalR2[1].
Molecular Weight

2287.61

Formula

C108H163N27O28
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

H2N-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

WTLNSAGYLLGPEHPPPALALA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (43.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4371 mL 2.1857 mL 4.3714 mL
5 mM 0.0874 mL 0.4371 mL 0.8743 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4371 mL 2.1857 mL 4.3714 mL 10.9284 mL
5 mM 0.0874 mL 0.4371 mL 0.8743 mL 2.1857 mL
10 mM 0.0437 mL 0.2186 mL 0.4371 mL 1.0928 mL
15 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7286 mL
20 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5464 mL
25 mM 0.0175 mL 0.0874 mL 0.1749 mL 0.4371 mL
30 mM 0.0146 mL 0.0729 mL 0.1457 mL 0.3643 mL
40 mM 0.0109 mL 0.0546 mL 0.1093 mL 0.2732 mL
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M871 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M871908844-75-7Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amideM 871M-871Neuropeptide Y ReceptorNPY receptorepilepsypainInhibitorinhibitorinhibit

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