CD42b Antibody (YA3686)
(Synonyms: GP1BA; BSS; GP1B; VWDP; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha)CD42b Antibody (YA3686) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD42b.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
CD42b Antibody (YA3686) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD42b.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 72 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 71.5 kDa
Purified recombinant fragment of human CD42B (AA: extra 17-183) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD42b (GPIbα) is a platelet membrane glycoprotein encoded by the GP1BA gene. It is the core functional subunit of the GPIb-IX-V complex responsible for directly recognizing and binding vWF. CD42b is mainly expressed in platelets and megakaryocytes, mediating the initial adhesion of platelets to the damaged vessel wall after vascular injury. It is a key initiation molecule for normal hemostasis and thrombosis. CD42b is not only an important pathogenic protein related to Bernard-Soulier syndrome, but also a classic biomarker in platelet function testing, AML-M7 immunophenotyping, and megakaryocyte differentiation research.
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Subunit
Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (PubMed:17008541, PubMed:2070794). Interacts with FLNB (PubMed:9651345). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450)
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SwissProt ID
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Synonyms
GP1BA; BSS; GP1B; VWDP; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha
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