1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

Cucurbitacin I (Synonyms: Elatericin B; JSI-124; NSC-521777)

Cat. No.: HY-N1405 Purity: >98.0%
Data Sheet SDS Handling Instructions

Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities.

For research use only. We do not sell to patients.
Cucurbitacin I Chemical Structure

Cucurbitacin I Chemical Structure

CAS No. : 2222-07-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $770 In-stock
1 mg $165 In-stock
5 mg $680 In-stock
10 mg $1200 In-stock
50 mg   Get quote  
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Other Forms of Cucurbitacin I:

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  • References

Description

Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities. IC50 value: Target: In vitro: Exposure of the COLO205 cells to cucurbitacin I significantly decreased cell viability. Furthermore our data demonstrated for the first time that in the COLO205 cells, cucurbitacin I could suppress the cell migration and invasion, and harbor chemosensitization activity against colon cancer. The anticancer activity of cucurbitacin I was accomplished by downregulating p-STAT3 and MMP-9 expression [1]. PE-induced cell enlargement and upregulation of ANF and β-MHC were significantly suppressed by pretreatment of the cardiomyocytes with cucurbitacin I. Notably, cucurbitacin I also impaired connective tissue growth factor (CTGF) and MAPK signaling, pro-hypertrophic factors, as well as TGF-β/Smad signaling, the important contributing factors to fibrosis. The protective impact of cucurbitacin I was significantly blunted in CTGF-silenced or TGF-β1-silenced hypertrophic cardiomyocytes, indicating that the compound exerts its beneficial actions through CTGF [2]. In vivo:

References
Molecular Weight

514.65

Formula

C₃₀H₄₂O₇

CAS No.

2222-07-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Cucurbitacin I
Cat. No.:
HY-N1405
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