1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

Cucurbitacin I (Synonyms: Elatericin B; JSI-124; NSC-521777)

Cat. No.: HY-N1405 Purity: >98.0%
Handling Instructions

Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities.

For research use only. We do not sell to patients.

Cucurbitacin I Chemical Structure

Cucurbitacin I Chemical Structure

CAS No. : 2222-07-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 924 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
1 mg USD 198 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 816 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 1440 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Other Forms of Cucurbitacin I:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities. IC50 value: Target: In vitro: Exposure of the COLO205 cells to cucurbitacin I significantly decreased cell viability. Furthermore our data demonstrated for the first time that in the COLO205 cells, cucurbitacin I could suppress the cell migration and invasion, and harbor chemosensitization activity against colon cancer. The anticancer activity of cucurbitacin I was accomplished by downregulating p-STAT3 and MMP-9 expression [1]. PE-induced cell enlargement and upregulation of ANF and β-MHC were significantly suppressed by pretreatment of the cardiomyocytes with cucurbitacin I. Notably, cucurbitacin I also impaired connective tissue growth factor (CTGF) and MAPK signaling, pro-hypertrophic factors, as well as TGF-β/Smad signaling, the important contributing factors to fibrosis. The protective impact of cucurbitacin I was significantly blunted in CTGF-silenced or TGF-β1-silenced hypertrophic cardiomyocytes, indicating that the compound exerts its beneficial actions through CTGF [2]. In vivo:

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9431 mL 9.7153 mL 19.4307 mL
5 mM 0.3886 mL 1.9431 mL 3.8861 mL
10 mM 0.1943 mL 0.9715 mL 1.9431 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

514.65

Formula

C₃₀H₄₂O₇

CAS No.

2222-07-3

SMILES

CC(C)(C1=CC[[email protected]@]2([H])[[email protected]@]3(C[[email protected]@H](O)[[email protected]@H]([[email protected]]3(C4)C)[[email protected]@](C)(O)C(/C=C/C(C)(O)C)=O)C)C(C(O)=C[[email protected]@]1([H])[[email protected]]2(C)C4=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Cucurbitacin I
Cat. No.:
HY-N1405
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