1. Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. PKC
    Apoptosis
  3. BJE6-106

BJE6-106 (Synonyms: B106)

Cat. No.: HY-117800
Handling Instructions

BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.

For research use only. We do not sell to patients.

BJE6-106 Chemical Structure

BJE6-106 Chemical Structure

CAS No. : 1564249-38-2

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Description

BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.

IC50 & Target

PKCδ

0.05 μM (IC50)

PKCα

50 μM (IC50)

In Vitro

BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations[1].
BJE6-106 (B106) (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells[1].
BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells[1].

Cell Viability Assay[1]

Cell Line: Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells
Concentration: 0.2 μM, 0.5 μM
Incubation Time: 24 hours, 48 hours, or 72 hours
Result: Inhibited cell survival in melanoma cell lines.

Apoptosis Analysis[1]

Cell Line: SBcl2 cells
Concentration: 0.2 μM, 0.5 μM
Incubation Time: 6 hours, 12 hours, or 24 hours
Result: Induced caspase 3/7 activation.

Western Blot Analysis[1]

Cell Line: SBcl2 cells
Concentration: 0.2 μM, 0.5 μM
Incubation Time: 2 hours, 5 hours, 10 hours
Result: Increased phosphorylation of MKK4, JNK and H2AX.
Molecular Weight

381.47

Formula

C₂₆H₂₃NO₂

CAS No.

1564249-38-2

SMILES

O=CC1=C2C(C=CC(C)(C)O2)=CC(CCN3C4=C(C5=C3C=CC=C5)C=CC=C4)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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BJE6-106
Cat. No.:
HY-117800
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