1. Immunology/Inflammation
    Apoptosis
  2. SphK
    Apoptosis
  3. SKI-I

SKI-I 

Cat. No.: HY-115735
Handling Instructions

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines.

For research use only. We do not sell to patients.

SKI-I Chemical Structure

SKI-I Chemical Structure

CAS No. : 306301-68-8

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Description

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].

IC50 & Target

IC50: 1.2 μM (ST-hSK); 11 μM (hERK2)[1]

In Vitro

SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99%[1].
SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.44

Formula

C₂₅H₁₈N₄O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SKI-I
Cat. No.:
HY-115735
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