306301-68-8
306301-68-8
Chemical Structure
SKI-I
- CAS No.: 306301-68-8
- Formula:C25H18N4O2
- Molecular Weight:406.44
IUPAC Name: (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)-5-(naphthalen-2-yl)-1H-pyrazole-3-carbohydrazide
InChIKey: XOXCTLAKMCIWCF-CVKSISIWSA-N
SMILES: O=C(C1=NNC(C2=CC=C3C=CC=CC3=C2)=C1)N/N=C/C4=C5C=CC=CC5=CC=C4O
Biological Activity: SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SKI-I | 99.73% | SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines. | ||||||||||||||||||||
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References
- [1]. French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9. [Content Brief]
- [2]. Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45(9):4149-56. [Content Brief]
Keywords
