1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. NSAH

NSAH 

Cat. No.: HY-114503 Purity: 98.62%
Handling Instructions

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.

For research use only. We do not sell to patients.

NSAH Chemical Structure

NSAH Chemical Structure

CAS No. : 1099592-35-4

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 720 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

In Vitro

NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells[1].
NSAH (0-10 μM, 2, 6, 24, or 72 h) exhibits potent anti-tumor activity in 3 cancer cell lines[1].
NSAH blocks S-phase progression well to the extent and timing of the decreases in dATP and dGTP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-231, HCT116 and Panc1 cancer cell lines.
Concentration: 0-10 μM.
Incubation Time: 2, 6, 24, or 72 h.
Result: Resulted in IC50 values ranging from 220 to 500 nM.
Molecular Weight

306.32

Formula

C₁₈H₁₄N₂O₃

CAS No.

1099592-35-4

SMILES

O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2646 mL 16.3228 mL 32.6456 mL
5 mM 0.6529 mL 3.2646 mL 6.5291 mL
10 mM 0.3265 mL 1.6323 mL 3.2646 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NSAHDNA/RNA SynthesisMDA-231HCT116Panc1S-phaseInhibitorinhibitorinhibit

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NSAH
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