(E/Z)-NSAH
(E/Z)-NSAH is an isoform of NSAH (HY-114503), which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 54009-54-0
- Formula: C18H14N2O3
- Molecular Weight:306.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
225 nM
Compound: E-3a
|
Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
|
[PMID: 29253340] |
| MDA-MB-231 | IC50 |
0.347 μM
Compound: E-3a
|
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
|
[PMID: 29253340] |
| MDA-MB-231 | IC50 |
1.43 μM
Compound: E-3a
|
Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay
|
[PMID: 29253340] |
| MDA-MB-231 | IC50 |
1.49 μM
Compound: E-3a
|
Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay
|
[PMID: 29253340] |
| MDA-MB-231 | IC50 |
1.94 μM
Compound: E-3a
|
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
|
[PMID: 29253340] |
| MDA-MB-231 | IC50 |
300 nM
Compound: E-3a
|
Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
|
[PMID: 29253340] |
Chemical Information
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CAS No. 54009-54-0
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Molecular Weight 306.32
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Formula C18H14N2O3
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SMILES
O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)