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Results for "

Panc1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (1) AP-1 (1) Apoptosis (7) Autophagy (1) Bacterial (2) Caspase (1) Cathepsin (1) CDK (1) DNA/RNA Synthesis (4) EGFR (1) Endogenous Metabolite (2) Ferroptosis (1) GLP Receptor (1) Glutathione Peroxidase (1) HDAC (1) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) IGF-1R (1) LIM Kinase (LIMK) (1) LXR (1) NF-κB (1) Phosphatase (1) Raf (1) Ras (2) Reactive Oxygen Species (2) ROCK (1) VEGFR (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (1) Infection (2) Metabolic Disease (3) Neurological Disease (2)

By Targets:

Akt (1)

Antibiotic (1)

AP-1 (1)

Apoptosis (7)

Autophagy (1)

Bacterial (2)

Caspase (1)

Cathepsin (1)

CDK (1)

DNA/RNA Synthesis (4)

EGFR (1)

Endogenous Metabolite (2)

Ferroptosis (1)

GLP Receptor (1)

Glutathione Peroxidase (1)

HDAC (1)

Hedgehog (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

IGF-1R (1)

LIM Kinase (LIMK) (1)

LXR (1)

NF-κB (1)

Phosphatase (1)

Raf (1)

Ras (2)

Reactive Oxygen Species (2)

ROCK (1)

VEGFR (1)

Xanthine Oxidase (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (1)

Infection (2)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19352

T56-LIMKi

1 Publications Verification

T5601640
LIM Kinase (LIMK) Cancer

T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC₅₀ of 35.2 μM.

T56-LIMKi 1 Publications Verification T5601640	LIM Kinase (LIMK)	Cancer
T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC₅₀ of 35.2 μM.

HY-N8034

Glychionide A	Apoptosis Autophagy	Cancer
Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer ^[1] .

HY-N1410

Triacetylresveratrol
Triacetylresveratrol, an acetylated analog of Resveratrol. Triacetylresveratrol decreases the phosphorylation of STAT3 and NF-κB in a dose- and time- dependent manner in PANC-1 and BxPC-3 cells. Anticancer effects ^[1].

HY-18597

LB-100 Maximum Cited Publications 7 Publications Verification	Phosphatase	Cancer
LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC₅₀ of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells ^[1] .

HY-N7287

(+)-Matairesinol

Others Others

(+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells ^[1].

(+)-Matairesinol	Others	Others
(+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells ^[1].

HY-155402

Antiproliferative agent-42	Caspase Apoptosis	Others
Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC₅₀ value of 12.54 μM ^[1].

HY-113978

6-Formylpterin	Xanthine Oxidase Apoptosis Reactive Oxygen Species	Metabolic Disease
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells ^[1].

HY-N8270

Physalin H	Hedgehog Endogenous Metabolite	Cancer
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively ^[1].

HY-127155

Kigamicin C	Bacterial Antibiotic	Infection Cancer
Kigamicin C is an anti-tumor antibiotic that selectively kills pancreatic cancer PANC-1 cells only in nutrient-poor conditions. Kigamicin C has antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) ^[1].

HY-146738

GSD-11	Akt	Cancer
GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].

HY-155020

Antitumor agent-101	Histone Methyltransferase GLP Receptor	Cancer
Antitumor agent-101 is a selective covalent inhibitor of lysine methyltransferases G9a/GLP, with IC₅₀s of 8.5 nM and 5.5 nM for G9a and GLP, respectively. Antitumor agent-101 shows antitumor efficacy in the PANC-1 xenograft model ^[1].

HY-152204

Cathepsin L/S-IN-1	Cathepsin	Cancer
Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC₅₀s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells ^[1].

HY-155990

Chb-M′ RUNX-IN-1	Apoptosis	Cancer
Chb-M′ (Compound Conjugate 1) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. Chb-M′ induces the p53-dependent apoptosis and inhibits cancer cell growth. Chb-M′ inhibits tumor growth in PANC-1 xenograft mice ^[1].

HY-113314

AFMK	Endogenous Metabolite	Cancer
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pK_a of AFMK at physiological pH is 8.7. Antioxidant capacity ^[1] . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .

HY-112666

Farnesyl thiosalicylic acid amide FTS amide; Salirasib amide	Ras	Cancer
Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC₅₀s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer ^[1].

HY-160061

P12FR2 aptamer sodium	Others	Cancer
P12FR2 aptamer sodium is a 2'-fluoropyrimidine-modified RNA aptamer targeting human PAUF with an estimated apparent KD of 77 nM. P12FR2 aptamer sodium inhibits PAUF-induced migration of PANC-1 (human pancreatic cancer cells) in wound healing assays and suppresses tumor growth in a mouse CFPAC-1 pancreatic cancer model ^[1].

HY-135453

(-)-Pinocembrin	Bacterial	Infection
(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC₅₀ value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC₅₀ values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines ^[1].

HY-155991

RUNX-IN-2	Apoptosis	Cancer
RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity ^[1].

HY-157740

XSJ-10	HDAC	Cancer
XSJ-10 is a HDAC inhibitor containing a RAS/RAF protein interfering unit, with IC_{50_s} of 0.05 and 0.04 μM in PANC-1 cells and HT-29 cells. XSJ-10 can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3 ^[1].

HY-139248

Paclitaxel octadecanedioate	Others	Cancer
Paclitaxel octadecanedioate (compound PTX-FA18) is comprised of Paclitaxel (HY-B0015) conjugated to 1,18-octadecanedioic acid (HY-W005178). Paclitaxel octadecanedioate mixed with human serum albumin (HAS) is cytotoxic to HT-1080, PANC-1, HT-29 and Hela cells (IC₅₀s = 12, 2.48, 8.62, and 64.42 nM, respectively) ^[1].

HY-147825

EGFR/BRAFV600E-IN-1	EGFR Raf Apoptosis	Cancer
EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAF ^V600E dual inhibitor with IC₅₀s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC₅₀s of 1.2, 0.79, 1.3, and 1.23 µM, respectively ^[1].

HY-135680

I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R	Metabolic Disease Cancer
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of *IGF-1R* (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀ of 1 µM ^[1].

HY-150640

Rho-Kinase-IN-2	ROCK	Neurological Disease
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC₅₀=3 nM). Rho-Kinase-IN-2 can be used in Huntington’s research ^[1].

HY-114503

NSAH	DNA/RNA Synthesis	Cancer
NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC₅₀ of 32 μM and cell-based IC₅₀ of ~250 nM, respectively ^[1].

HY-114503A

(E/Z)-NSAH	DNA/RNA Synthesis	Cancer
(E/Z)-NSAH is an isoform of NSAH (HY-114503), which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC₅₀ of 32 μM and cell-based IC₅₀ of ~250 nM, respectively ^[1].

HY-160038

GAC0003A4	LXR	Cancer
GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies ^[1].

HY-144661

KRAS G12D inhibitor 14	Ras Apoptosis	Cancer
KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a K_D of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D ^[1].

HY-120118

Metarrestin ML246	DNA/RNA Synthesis	Cancer
Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models ^[1] .

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research ^[1].

HY-19357

E3330 2 Publications Verification APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Cancer
E3330 (APX-3330) is a direct, orally active and selective inhibitor of **Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α** in pancreatic cancer. E3330 shows anticancer activities ^[1] .

HY-147409

Ulecaciclib	CDK	Cancer
Ulecaciclib is an orally activitive inhibitor of cyclin-dependent kinase (CDK), with K_i values of 0.62 μM (CDK2/Cyclin A), 0.2 nM (CDK4/Cyclin D1), 3 nM (CDK6/Cyclin D3), and 0.63 μM (CDK7/Cyclin H), respectively. Ulecaciclib can cross blood brain barrier and has good pharmacokinetic characteristics ^[1] .

CPF-7 Caerulein precursor fragment	Peptides	Metabolic Disease
CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes ^[1] .

Glychionide A	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis Autophagy
Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer ^[1] .

AFMK	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pK_a of AFMK at physiological pH is 8.7. Antioxidant capacity ^[1] . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .

(+)-Matairesinol	Thymelaeaceae Source classification Lignans Phenylpropanoids Plants Wikstroemia indica	Others
(+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells ^[1].

Physalin H	Structural Classification Cardiacglycosides Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively ^[1].

Kigamicin C	Structural Classification Microorganisms Source classification Lignans Phenylpropanoids	Bacterial Antibiotic
Kigamicin C is an anti-tumor antibiotic that selectively kills pancreatic cancer PANC-1 cells only in nutrient-poor conditions. Kigamicin C has antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) ^[1].

(-)-Pinocembrin	Structural Classification Flavonoids Flavones Polygonaceae Source classification Persicaria glabra (Willd.) M. Gomez Plants	Bacterial
(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC₅₀ value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC₅₀ values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines ^[1].

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