2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Cathepsin L/S-IN-1

Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells.

For research use only. We do not sell to patients.

Cathepsin L/S-IN-1 Chemical Structure

Cathepsin L/S-IN-1 Chemical Structure

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Cathepsin L/S-IN-1 Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells[1].

IC50 & Target[1]

cathepsin L

4.10 μM (IC50)

cathepsin S

1.79 μM (IC50)

In Vitro

Cathepsin L/S-IN-1 (compound B1a) (0-25 μM; 48 h) shows noncytotoxic agaisnt pancreatic cancer BxPC-3 and PANC-1 cells[1].
Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits Cathepsin L and S activities without decreasing the mRNA level of them[1].
Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits the migration and invasion of pancreatic cancer BxPC-3 and PANC-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cathepsin L/S-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: BxPC-3 and PANC-1 cells
Concentration: 0, 6.25, 12.5, and 25 μM
Incubation Time: 48 hours
Result: Failed to suppress the viability of pancreatic cancer cells.
Molecular Weight

613.57

Formula

C29H33BrN4O4S
SMILES

O[C@@H](COC[C@H](NS(=O)(C1=CC=C(C=C1)Br)=O)CC2=CC=CC=C2)CN(CC3)CCN3C(C=CC=C4)=C4C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cathepsin L/S-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathepsin L/S-IN-1CathepsinInhibitorinhibitorinhibit

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Cathepsin L/S-IN-1
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