1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. E3330

E3330 (Synonyms: APX-3330)

Cat. No.: HY-19357
Handling Instructions

E3330 (APX-3330) is a direct, orally active AP endonuclease 1 (APE1; also known as REF-1) inhibitor, which suppresses NF-κB DNA-binding activity. E3330 (APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330 (APX-3330) shows anticancer properties, such as inhibition of cancer cell growth and migration[1-4].

For research use only. We do not sell to patients.

E3330 Chemical Structure

E3330 Chemical Structure

CAS No. : 136164-66-4

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Description

E3330 (APX-3330) is a direct, orally active AP endonuclease 1 (APE1; also known as REF-1) inhibitor, which suppresses NF-κB DNA-binding activity. E3330 (APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330 (APX-3330) shows anticancer properties, such as inhibition of cancer cell growth and migration[1-4].

IC50 & Target

DNA Synthesis, APE1[1-4]

Molecular Weight

378.46

Formula

C₂₁H₃₀O₆

CAS No.

136164-66-4

SMILES

CCCCCCCCC/C(C(O)=O)=C\C1=C(C)C(C(OC)=C(OC)C1=O)=O

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

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E3330
Cat. No.:
HY-19357
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