1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. E3330

E3330 (Synonyms: APX-3330)

Cat. No.: HY-19357 Purity: 98.01%
Handling Instructions

E3330 (APX-3330) is a direct, orally active and selective AP endonuclease 1 (APE1; REF-1) inhibitor, which suppresses NF-κB DNA-binding activity. E3330 (APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330 (APX-3330) shows anticancer properties, such as inhibition of cancer cell growth and migration.

For research use only. We do not sell to patients.

E3330 Chemical Structure

E3330 Chemical Structure

CAS No. : 136164-66-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
5 mg USD 135 In-stock
Estimated Time of Arrival: December 31
10 mg USD 215 In-stock
Estimated Time of Arrival: December 31
50 mg USD 635 In-stock
Estimated Time of Arrival: December 31
100 mg USD 995 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

E3330 (APX-3330) is a direct, orally active and selective AP endonuclease 1 (APE1; REF-1) inhibitor, which suppresses NF-κB DNA-binding activity. E3330 (APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330 (APX-3330) shows anticancer properties, such as inhibition of cancer cell growth and migration[1][2][3][4].

IC50 & Target

APE1[1]

Clinical Trial
Molecular Weight

378.46

Formula

C₂₁H₃₀O₆

CAS No.

136164-66-4

SMILES

CCCCCCCCC/C(C(O)=O)=C\C1=C(C)C(C(OC)=C(OC)C1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (660.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6423 mL 13.2114 mL 26.4229 mL
5 mM 0.5285 mL 2.6423 mL 5.2846 mL
10 mM 0.2642 mL 1.3211 mL 2.6423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

E3330APX-3330E 3330E-3330APX3330APX 3330DNA/RNA SynthesisorallyAPendonuclease1APE1REF-1NF-κBDNA-bindingTNF-αIL-8anticancerInhibitorinhibitorinhibit

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Product Name:
E3330
Cat. No.:
HY-19357
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