DNA-binding

By Targets:	DNA Alkylator/Crosslinker (4) DNA Stain (1) DNA/RNA Synthesis (4) ADC Cytotoxin (1) Androgen Receptor (3) Antibiotic (2) AP-1 (2) Apoptosis (7) Aryl Hydrocarbon Receptor (1) Autophagy (1) Bacterial (6) Bcl-2 Family (1) Biochemical Assay Reagents (1) c-Myc (1) COX (1) Early 2 Factor (E2F) (1) EBV (2) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Fluorescent Dye (2) Glutathione S-transferase (1) HIF/HIF Prolyl-Hydroxylase (3) HIV (3) HSP (1) IFNAR (1) IGF-1R (1) IKK (1) Influenza Virus (1) MDM-2/p53 (6) Melatonin Receptor (1) MMP (2) NF-κB (10) Nucleoside Antimetabolite/Analog (2) PROTACs (1) RAR/RXR (1) Reactive Oxygen Species (5) RET (1) ROR (1) STAT (5) Survivin (1) Topoisomerase (3) VEGFR (1)
By Research Areas:	Cancer (56) Cardiovascular Disease (2) Endocrinology (1) Infection (11) Inflammation/Immunology (11) Neurological Disease (2)
Click Chemistry:	Azide (1)

Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain Penicillin-binding protein (PBP) DNA Alkylator/Crosslinker DNA/RNA Synthesis FKBP FABP Transthyretin (TTR) Ligands for Target Protein for PROTAC YB-1 P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6046

Kamebakaurin	NF-κB	Inflammation/Immunology Cancer
Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50 .

HY-D1444

Propidium monoazide	Fluorescent Dye	Infection
Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-18371

TC-S 7009	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
TC-S 7009 is a potent and selective HIF-2α inhibitor with a K_d of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (K_d ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression .

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-160129

Centanamycin ML-970; AS-I-145; NSC 716970	Nucleoside Antimetabolite/Analog	Cancer
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening .

HY-N0629

Maslinic acid 5+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-16667

HLM006474

3 Publications Verification

Early 2 Factor (E2F) Cancer

HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC₅₀ of 29.8 µM in A375 cells.

HLM006474 3 Publications Verification	Early 2 Factor (E2F)	Cancer
HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC₅₀ of 29.8 µM in A375 cells.

HY-15620

Methylproamine 1 Publications Verification	DNA/RNA Synthesis	Others
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	DNA/RNA Synthesis	Cancer
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-161252

PBD-monoamide	ADC Cytotoxin	Cancer
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability .

HY-106101

Echinomycin 4 Publications Verification Quinomycin A; NSC-13502	HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial	Cancer
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM .

HY-146020

Topoisomerase IIα-IN-1	Topoisomerase	Cancer
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines .

HY-156135

NSC194598	RET	Others
NSC194598 is a p53 DNA-binding inhibitor with IC₅₀ value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research .

HY-116501

VPC-14449	Androgen Receptor	Cancer
VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC₅₀ of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer .

HY-162265

UCM-13369	Apoptosis	Cancer
UCM-13369 (Compound 4b) is a NPM1 inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells, that can be used for the research of AML .

HY-156483

TT-012	Others	Cancer
TT-012 specifically binds to dynamic MITF and destroys the latter's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models .

HY-146021

Topoisomerase IIα-IN-2	Topoisomerase	Cancer
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase .

HY-100609

4-P-PDOT 5 Publications Verification	Melatonin Receptor	Neurological Disease
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity) .

HY-N8146

Bruceantinol	STAT	Infection Cancer
Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper . Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc .

HY-153202

SLMP53-2	MDM-2/p53 Apoptosis	Cancer
SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity .

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-N3989

Haplopine

Bacterial Infection

Haplopine possesses photo-activated antimicrobial and DNA binding activities .

Haplopine	Bacterial	Infection
Haplopine possesses photo-activated antimicrobial and DNA binding activities .

HY-125636

Mycro1	Others	Cancer
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .

HY-126979

Mycro2	Others	Cancer
Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .

HY-124179

IT-901	NF-κB	Cancer
IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC₅₀ of 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD) .

HY-P5343

p53 CBS

p53 Consensus binding sequence
MDM-2/p53 Others

p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

p53 CBS p53 Consensus binding sequence	MDM-2/p53	Others
p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

HY-43058

5'-O-DMT-ibu-rG 5'-O-DMT-N2-isobutyrylguanosine	Nucleoside Antimetabolite/Analog	Others
5'-O-DMT-ibu-rG is a useful model for a new class of DNA binding molecules for the development of potent and selective anti-cancer agents .

HY-19770

GSK2981278 3 Publications Verification	ROR	Inflammation/Immunology
GSK2981278 is a potent and selective RORγ inverse agonist. GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding .

HY-10074

TPCA-1 20+ Cited Publications	IKK STAT Apoptosis	Inflammation/Immunology Cancer
TPCA-1 is a potent and selective inhibitor of IKK-2 with IC₅₀ of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

HY-144333

DNA crosslinker 1 dihydrochloride	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 1 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.1 °C. DNA crosslinker 1 (dihydrochloride) can be used for researching anticancer .

HY-125633

Kapurimycin A3	Antibiotic Bacterial	Infection Cancer
Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces .

HY-144336

DNA crosslinker 3 dihydrochloride	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .

HY-N4058

Helichrysetin	Apoptosis	Cancer
Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity .

HY-18061

Ochromycinone 1 Publications Verification (Rac)-STA-21	STAT Bacterial	Infection Cancer
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity .

HY-D0917

TO-PRO 1	DNA Stain	Cancer
TO-PRO 1 is a DNA binding fluorochrome, that atached to the surface of the Feraheme (FH) nanoparticle (NP), to obtain a fluorochrome-functionalized NP. TO-PRO 1 binds DNA through intercalation, and acts as a vital fluorochrome for necrotic cells .

HY-100669

Mycro 3 5 Publications Verification	c-Myc Autophagy	Cancer
Mycro 3 is an orally active, potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc . Mycro 3 could be used for the research of pancreatic cancer .

HY-137877

7-Acetoxy-4-methylcoumarin 4-Methylumbelliferyl acetate	Glutathione S-transferase	Others
7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition .

HY-12684

CH-223191 Maximum Cited Publications 51 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

HY-118581

Coralyne chloride	Topoisomerase	Cancer
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes .

HY-118618

Eucannabinolide Hiyodorilactone A; Schkuhrin I	STAT	Cancer
Eucannabinolide is a STAT3 inhibitor. Eucannabinolide suppresses STAT3 activation at tyrosine 705, inhibiteds its translocation to nucleus, and decreases its DNA binding capacity. Eucannabinolide can be used for triple negative breast cancer (TNBC) diseases research .

HY-W029719

[5-(2-Thienyl)-3-isoxazolyl]methanol	Bacterial	Infection
[5-(2-Thienyl)-3-isoxazolyl]methanol (Compound D) is an *AgrA-DNA* binding inhibitor. [5-(2-Thienyl)-3-isoxazolyl]methanol can be used for S.aureus infection research .

HY-117669

VPC-14228	Androgen Receptor	Cancer
VPC-14228 is a potent androgen receptor DNA binding domain (AR-DBD) inhibitor that interferes with the interaction of AR with androgen response elements and effectively blocks AR transcriptional activity. VPC-14228 can be used in prostate cancer research .

HY-A0068

Aurothioglucose 1 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-119970

Helenalin 4 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-144707

AK-778-XXMU	Apoptosis	Cancer
AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a K_D of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth .

HY-124651

SEMBL	NF-κB MMP	Inflammation/Immunology Cancer
SEMBL is a potent NF-κB inhibitor. SEMBL can inhibit NF-κB-DNA binding, and also inhibits NF-κB-dependent inflammatory cytokine secretions. SEMBL inhibits cancer cell migration and invasion via decreasing MMP expression. SEMBL can be used for researching anticancer .

HY-125471

VK-1727	EBV	Infection Inflammation/Immunology Cancer
VK-1727 is a selective small molecule inhibitor of EBNA1. VK-1727 can reduce EBNA1 DNA binding activity. VK-1727 selectively blocks the proliferation and metabolic activity of EBV+ cells, instead of EBV- cells. VK-1727 is used in multiple sclerosis research .

HY-107999

CADD522 1 Publications Verification	Reactive Oxygen Species	Cancer
CADD522 is a *RUNX2-DNA* binding inhibitor (downregulates RUNX2-mediated transcription of downstream target genes), with an IC₅₀ of 10 nM. CADD522 inhibits primary tumor growth and experimental metastasis of tumor cells in the lungs of immune-compromised mice. CADD522 can be used in study of cancer .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-144335

DNA crosslinker 2 dihydrochloride	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .

Cat. No.	Product Name

HY-L008

JAK/STAT Compound Library

423 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Product Name	Type

HY-D1444

Propidium monoazide

DNA Stain

Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-D0917

TO-PRO 1	DNA Stain
TO-PRO 1 is a DNA binding fluorochrome, that atached to the surface of the Feraheme (FH) nanoparticle (NP), to obtain a fluorochrome-functionalized NP. TO-PRO 1 binds DNA through intercalation, and acts as a vital fluorochrome for necrotic cells .

HY-147114

3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin	Fluorescent Dyes/Probes
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is a DNA uptake tracer, a pteridine-based fluorescent guanosine analogue. 3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is widely used in studies of DNA binding and dynamics, with an absorbance maximum at 350 nm and an emission maximum at 430 nm .

Cat. No.	Product Name	Type

HY-15620

Methylproamine 1 Publications Verification	Biochemical Assay Reagents
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .

Cat. No.	Product Name	Target	Research Area

HY-P5343

p53 CBS

p53 Consensus binding sequence
MDM-2/p53 Others

p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

Cat. No.	Product Name	Target	Research Area

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-P990021

Calpurbatug	Inhibitory Antibodies	Others
Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6046

Kamebakaurin	Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Baccharis densiflora Wedd. Inflammation/Immunology Disease Research Fields Cancer	NF-κB
Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50 .

HY-N0629

Maslinic acid Maximum Cited Publications 9 Publications Verification Crategolic acid; 2α-Hydroxyoleanolic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	NF-κB Bacterial HIV Endogenous Metabolite
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	STAT
Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper . Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc .

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-N3989

Haplopine	Infection Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Quinoline Alkaloids Plants Disease Research Fields	Bacterial
Haplopine possesses photo-activated antimicrobial and DNA binding activities .

HY-125633

Kapurimycin A3	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces .

HY-N4058

Helichrysetin	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Cancer Zingiberaceae	Apoptosis
Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity .

HY-18061

Ochromycinone 1 Publications Verification (Rac)-STA-21	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Disease Research Fields	STAT Bacterial
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity .

HY-118618

Eucannabinolide Hiyodorilactone A; Schkuhrin I	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Guilandina minax (Hance) G. P. Lewis	STAT
Eucannabinolide is a STAT3 inhibitor. Eucannabinolide suppresses STAT3 activation at tyrosine 705, inhibiteds its translocation to nucleus, and decreases its DNA binding capacity. Eucannabinolide can be used for triple negative breast cancer (TNBC) diseases research .

HY-119970

Helenalin 4 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-N0908

Ginsenoside Rg5 1 Publications Verification	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Endocrinology Araliaceae	IGF-1R NF-κB COX
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

Species:	Human (10) E.coli (1)
Tag:	SUMO (2) His (7) Tag Free (3) Strep (1) Flag (1)
Source:	HEK293 (2) P. pastoris (1) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P71497

	DNA-binding protein HU-alpha Protein, E.coli (His-SUMO) hupA; Z5576; ECs4923DNA-binding protein HU-alpha; HU-2; NS2	E.coli	E. coli
	DNA-binding protein HU-alpha, a histone-like DNA-binding protein, wraps DNA, offering stabilization and preventing denaturation in challenging conditions. Comprising alpha and beta chains in a heterodimer, it demonstrates versatile DNA binding and protective functions. DNA-binding protein HU-alpha Protein, E.coli (His-SUMO) is the recombinant E. coli-derived DNA-binding protein HU-alpha protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of DNA-binding protein HU-alpha Protein, E.coli (His-SUMO) is 90 a.a., with molecular weight of ~27 kDa.

HY-P71177

	Nucleobindin-2 Protein, Human Nucleobindin-2; DNA-binding protein NEFA; Gastric cancer antigen Zg4; Prepronesfatin; Nesfatin-1; NUCB2; NEFA	Human	E. coli
	Nucleobindin-2 protein is a calcium-binding molecule that may contribute to calcium homeostasis and act as a non-receptor guanine nucleotide exchange factor. Its interaction with the guanine nucleotide-binding protein (G protein) α subunit GNAI3 suggests its role in activating the G protein signaling pathway. Nucleobindin-2 Protein, Human is the recombinant human-derived Nucleobindin-2 protein, expressed by E. coli , with tag free. The total length of Nucleobindin-2 Protein, Human is 82 a.a., with molecular weight of ~10.0 kDa.

HY-P71124

	NFKB1 Protein, Human (His) DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Human	E. coli
	The NFKB1 protein is a subunit of NF-kappa-B and regulates transcription in a variety of biological processes. It forms homodimeric or heterodimeric complexes with RELA/p65, RELB, and NFKB2/p52. NFKB1 Protein, Human (His) is the recombinant human-derived NFKB1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NFKB1 Protein, Human (His) is 434 a.a., with molecular weight of 45-55 kDa.

HY-P701528

	HLTF Protein, Human HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free. The total length of HLTF Protein, Human is 117 a.a., .

HY-P701529

	HLTF Protein, Human (His) HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of HLTF Protein, Human (His) is 117 a.a., .

HY-P701614

	WDHD1 Protein, Human (HEK293, FLAG) WDHD1; WD repeat and HMG-box DNA-binding protein 1; Acidic nucleoplasmic DNA-binding protein 1; And-1	Human	HEK293
	WDHD1 Protein is a core replisome component that serves as a replication initiation factor. It directly binds to the CMG complex, acting as a hub to recruit other proteins to the replication fork. WDHD1 interacts with POLA1, MCM10, DNA2, CDC45, and GINS2, linking it to the CMG helicase complex. WDHD1 Protein, Human (HEK293, FLAG) is the recombinant human-derived WDHD1 protein, expressed by HEK293 , with C-Flag labeled tag. The total length of WDHD1 Protein, Human (HEK293, FLAG) is 1128 a.a., .

HY-P701615

	WDHD1 Protein, Human (HEK293, His, Strep) WDHD1; WD repeat and HMG-box DNA-binding protein 1; Acidic nucleoplasmic DNA-binding protein 1; And-1	Human	HEK293
	WDHD1 Protein is a core replisome component that serves as a replication initiation factor. It directly binds to the CMG complex, acting as a hub to recruit other proteins to the replication fork. WDHD1 interacts with POLA1, MCM10, DNA2, CDC45, and GINS2, linking it to the CMG helicase complex. WDHD1 Protein, Human (HEK293, His, Strep) is the recombinant human-derived WDHD1 protein, expressed by HEK293 , with N-10*His, N-Strep labeled tag. The total length of WDHD1 Protein, Human (HEK293, His, Strep) is 1128 a.a., .

HY-P71788

	TARDBP Protein, Human (P.pastoris, His) ALS10; TAR DNA binding protein 43; TAR DNA binding protein; TAR DNA-binding protein 43; TARDBP; TDP 43; TDP-43; TDP43	Human	P. pastoris
	TARDBP protein is an RNA-binding factor with RRM1 and RRM2 that binds GU repeats and regulates RNA splicing in long introns and 3'UTRs. It affects proteins critical for neuronal survival and neurodegenerative diseases. TARDBP Protein, Human (P.pastoris, His) is the recombinant human-derived TARDBP protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of TARDBP Protein, Human (P.pastoris, His) is 396 a.a., with molecular weight of ~44.9 kDa.

HY-P71135

	NFYA Protein, Human Nuclear Transcription Factor Y Subunit Alpha; CAAT Box DNA-binding Protein Subunit A; Nuclear Transcription Factor Y Subunit A; NF-YA; NFYA	Human	E. coli
	The NFYA protein is a component of the NF-Y transcription factor and recognizes the 5'-CCAAT-3' box motif in gene promoters. NFYA functions as an activator or repressor depending on the interacting cofactors. NFYA Protein, Human is the recombinant human-derived NFYA protein, expressed by E. coli , with tag free. The total length of NFYA Protein, Human is 318 a.a., with molecular weight of 40 & 60 & 70 kDa, respectively.

HY-P71588

	CHD1L Protein, Human (His-SUMO) ALC1; Amplified in liver cancer 1; Amplified in liver cancer protein 1; chd1l; CHD1L_HUMAN; CHDL; Chromodomain helicase DNA binding protein 1 like; Chromodomain-helicase-DNA-binding protein 1-like; FLJ22530	Human	E. coli
	CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of CHD1L Protein, Human (His-SUMO) is 194 a.a., with molecular weight of ~37.3 kDa.

HY-P71436

	ZBP1 Protein, Human (His) Z-DNA-binding Protein 1; Tumor Stroma and Activated Macrophage Protein DLM; ZBP1; C20orf183; DLM1	Human	E. coli
	ZBP1 is an important innate sensor that defends against viruses by recognizing Z-RNA structures and inducing PANoptosis. It binds Z-RNA through TNF-α family members and stimulates RIPK3 and MLKL to activate necroptosis. ZBP1 Protein, Human (His) is the recombinant human-derived ZBP1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of ZBP1 Protein, Human (His) is 149 a.a., with molecular weight of 16-23 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80553

ATF4 Antibody Cyclic AMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
ATF4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 39 kDa, targeting to ATF4. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P81409

SATB1 Antibody (YA1154)

DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)
IHC-P Human

HY-P83100

ID1 Antibody (YA2845) DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; ID1; BHLHB24; ID	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P80764

NF-KB p105 Antibody (YA700) NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	WB	Human, Mouse, Rat
NF-KB p105 Antibody (YA700) is a non-conjugated and Mouse origined monoclonal antibody about 105 kDa, targeting to NF-KB p105 (5E3). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81049

Phospho-NFKB1(Ser337) Antibody NFKB1; NF-KB; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit; NFkB p105 / p50; NFkB p105/p50; nuclear factor kappa B subunit 1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta	WB, IHC-P, IHC-F, Flow-Cyt, IF, ELISA	Human, Mouse (predicted: Rat, Pig, Cow)
Phospho-NFKB1 p105/p50 (Ser337) Antibody is an unconjugated, approximately 50&120 kDa, rabbit-derived, anti-NFKB1 p105/p50 (Ser337) polyclonal antibody. Phospho-NFKB1 p105/p50 (Ser337) Antibody can be used for: WB, IHC-P, ICC/IF expriments in human, mouse, rat background without labeling.

HY-P80936

YB1 Antibody YBX1; NSEP1; YB1; Nuclease-sensitive element-binding protein 1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
YB1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 36 kDa, targeting to YB1. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80763

NF-KB p100 Antibody NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10	WB, ICC/IF, IP	Human, Mouse, Rat
NF-KB p100 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 97 kDa, targeting to NF-KB p100. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81282

Ikaros Antibody (YA987) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (Ikaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	WB, IP	Human

HY-P81282A

Ikaros Antibody (YA988) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (Ikaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	IHC-P	Human

HY-P81651

NFYA Antibody (YA1396)

NFYA; Nuclear transcription factor Y subunit alpha; CAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YA
WB, IP Human, Mouse, Rat
HY-P82753

Phospho-KIF22 (Ser427) Antibody (YA2498)

KIF22; KID; KNSL4; Kinesin-like protein KIF22; Kinesin-like DNA-binding protein; Kinesin-like protein 4
WB Human
HY-P81842

GATA1 Antibody (YA1587)

GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
WB, ICC/IF, IP, ChIP Human

HY-P82486

TNFAIP3 Antibody (YA2231) TNFAIP3; OTUD7C; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20	WB, IHC-F, IHC-P, ICC/IF	Human

HY-P81265

CHD4 Antibody (YA946)

CHD4; Chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
WB, IP Human
HY-P81265A

CHD4 Antibody (YA947)

CHD4; Chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
WB, ICC/IF, FC Human

HY-P81264

CHD3 Antibody (YA944) CHD3; Chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P81264A

CHD3 Antibody (YA945) CHD3; Chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P81173

TWIST Antibody ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS1; H-twist; OTTHUMP00000116043; SCS; Twist basic helix loop helix transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; Twist1; TWST1_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat,
TWIST Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-TWIST polyclonal antibody. TWIST Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, background without labeling.

Cat. No.	Product Name		Classification

HY-D1444

Propidium monoazide		Azide
Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.


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