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  4. TWIST Antibody

TWIST Antibody is an unconjugated, approximately 23 kDa, mouse-derived, anti-TWIST monoclonal antibody. TWIST Antibody can be used for: WB, IHC-P, ICC/IF, FC expriments in human, mouse background without labeling.

For research use only. We do not sell to patients.

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Description

TWIST Antibody is an unconjugated, approximately 23 kDa, mouse-derived, anti-TWIST monoclonal antibody. TWIST Antibody can be used for: WB, IHC-P, ICC/IF, FC expriments in human, mouse background without labeling.

Background

The related gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of related genes involved in cranial suture closure during skull development. The protein may also regulate neural tube closure, limb development and brown fat metabolism. The related gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in The related gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.

Gene ID

7291

Synonyms
ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS1; H-twist; OTTHUMP00000116043; SCS; Twist basic helix loop helix transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; Twist1; TWST1_HUMAN.
Molecular Weight

Predicted band size: 23kDa

Purity

affinity purified

Subcellular Location

Nucleus.

Conjugation

Non-conjugated

Modification

Unmodified

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Clonality

Monoclonal

Host

Mouse

Reactivity

Human, Mouse

SwissProt ID

Q15672

Dilution Ratio

WB: 1/500-1/1000; IHC: 1/100-1/200; IF: 1/50-1/200; FC: 1/50-1/100;

Application

WB, IHC-P, ICC/IF, FC

Positive Control

Human TWIST1 recombinant protein, TWIST1-hIgGFc transfected HEK293 cell lysate, NIH/3T3, JURKAT, HeLa, A549, RAJI, OCM-1, cervical cancer tissue,

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG1

Sensitivity

Endogenous

Immunogen

Purified recombinant fragment of human TWIST1 expressed in E. Coli.

Documentation

TWIST Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TWIST Antibody
Cat. No.:
HY-P81173
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