TWIST1 - twist family bHLH transcription factor 1 Gene

Also Known as CRS; CSO; SCS; ACS3; CRS1; BPES2; BPES3; SWCOS; TWIST; bHLHa38

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7291

About TWIST1

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:19,113,047-19,117,636 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues, 13 paralogues and is associated with 8 phenotypes. Biased expression in fat (RPKM 17.1), endometrium (RPKM 12.4) and 10 other tissues.

Summary

This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020]

TWIST1 Products (1)

mRNA	Protein	Name
NM_000474.4	NP_000465.1	twist-related protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17332325	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15545268	GOA
enables DNA-binding transcription repressor activity	IDA IDA: Inferred from direct assay	27027434	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	17332325	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	10749989	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27027434	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10749989	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	20804746	GOA
involved in cell proliferation involved in heart valve development	IMP IMP: Inferred from mutant phenotype	20804746	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	18297062	GOA
involved in embryonic camera-type eye formation	IMP IMP: Inferred from mutant phenotype	17070479	GOA
involved in embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	8988166	GOA
involved in eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	17070479	GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17690110	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	25981568	GOA
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	17690110	GOA
involved in negative regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	17690110	GOA
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	27027434	GOA
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	16888803	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17003487	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17690110	GOA
involved in positive regulation of DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	17332325	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17332325	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	18297062	GOA
involved in positive regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	20007935	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17003487	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	20007935	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	20007935	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17332325	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12270142	GOA
involved in positive regulation of transcription regulatory region DNA binding	IMP IMP: Inferred from mutant phenotype	12270142	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	20007935	GOA
involved in regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	19597909	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10749989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TWIST1 Protein Structure

HLH

0
100
202 a.a.

Protein Preferred Names	Protein Names
twist-related protein 1	B-HLH DNA binding protein

TWIST1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TWIST1	Q15672	G3BP2	Homo sapiens	Q9UN86	Anti Bait CoIP	25893917
Intra	TWIST1	Q15672	KMT5A	Homo sapiens	Q9NQR1	Pull Down	21983900
Intra	TWIST1	Q15672	ETS2	Homo sapiens	P15036	Anti Tag CoIP	18598946
Intra	TWIST1	Q15672	TP53	Homo sapiens	P04637	Filter Binding	18504427
Intra	TWIST1	Q15672	TP53	Homo sapiens	P04637	Pull Down	22975381
Intra	TWIST1	Q15672	TP53	Homo sapiens	P04637	Anti Bait CoIP	18504427
Intra	TWIST1	Q15672	TP53	Homo sapiens	P04637	Anti Bait CoIP	22975381
Intra	TWIST1	Q15672	TP53	Homo sapiens	P04637	Anti Tag CoIP	18504427
Intra	TWIST1	Q15672	TP53	Homo sapiens	P04637	Pull Down	25402006
Intra	TWIST1	Q15672	KAT5	Homo sapiens	Q92993	Acetylase Assay	24525235
Intra	TWIST1	Q15672	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	18504427
Intra	TWIST1	Q15672	TCF4	Homo sapiens	P15884	Pull Down	19534813
Intra	TWIST1	Q15672	TCF4	Homo sapiens	P15884	Pull Down	25402006
Intra	TWIST1	Q15672	TCF4	Homo sapiens	P15884	Y2H	19534813
Intra	TWIST1	Q15672	TCF4	Homo sapiens	P15884	Confocal	19534813
Intra	TWIST1	Q15672	BRD4	Homo sapiens	O60885	Anti Bait CoIP	24525235
Intra	TWIST1	Q15672	BRD4	Homo sapiens	O60885	NMR	24525235
Intra	TWIST1	Q15672	BRD4	Homo sapiens	O60885	Anti Tag CoIP	24525235
Intra	TWIST1	Q15672	TCF3	Homo sapiens	P15923-1	Pull Down	10749989
Intra	TWIST1	Q15672	TCF3	Homo sapiens	P15923-1	Anti Bait CoIP	10749989
Intra	TWIST1	Q15672	TCF3	Homo sapiens	P15923-1	Confocal	11248247
Intra	TWIST1	Q15672	TCF3	Homo sapiens	P15923-1	Pull Down	11248247
Intra	TWIST1	Q15672	TCF3	Homo sapiens	P15923-1	Confocal	10749989
Intra	TWIST1	Q15672	BRD4	Homo sapiens	O60885-1	Pull Down	24525235
Intra	TWIST1	Q15672	BRD4	Homo sapiens	O60885-1	Anti Tag CoIP	24525235

Cross: Cross-species interaction Intra: Intraspecies interaction

TWIST1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81173	TWIST1 Antibody (YA3398)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P84596	TWIST1 Antibody (YA4293)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P84596A	TWIST1 Antibody (YA4293)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P86342	TWIST1 Antibody (YA6034)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Saethre-Chotzen Syndrome	SCS Acs3 Acs Iii Chotzen Syndrome Acrocephaly, Skull Asymmetry, And Mild Syndactyly Acrocephalosyndactyly Type 3 Acrocephalosyndactyly, Type Iii Acrocephalosyndactyly Type Iii Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies Auralcephalosyndactyly Acs 3 Acrocephalo-Syndactyly, Type 3 Blepharophimosis,Epicanthus Inversus, And Ptosis 3 Aural Cephalosyndactyly Kurczynski-Casperson Syndrome Acrocephalosyndactyly Iii Dysostosis Craniofacialis With Hypertelorism Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies Sakati Syndrome
Sweeney-Cox Syndrome	SWCOS
Craniosynostosis 1	CRS Congenital Rubella Syndrome Craniostenosis Congenital Rubella CRS1 Craniosynostosis, Type 1 Rubella Congenital Fetal Rubella Syndrome Mother-To-Child Transmission Of Rubella Syndrome Rubella, Congenital Craniosynostosis Gregg Syndrome
Robinow-Sorauf Syndrome	Craniosynostosis-Bifid Hallux Syndrome Acrocephalosyndactyly, Robinow-Sorauf Type RSS Acrocephalosyndactyly Robinow-Sorauf Type Robinow Sorauf Syndrome
Non-Syndromic Sagittal Craniosynostosis	Isolated Sagittal Craniosynostosis Isolated Scaphocephaly Non-Syndromic Sagittal Suture Synostosis
Non-Syndromic Bicoronal Craniosynostosis	Isolated Bicoronal Craniosynostosis Isolated Brachycephaly Non-Syndromic Bilateral Coronal Suture Synostosis
Synostosis
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Baller-Gerold Syndrome	BGS Craniosynostosis With Radial Defects Craniosynostosis-Radial Aplasia Syndrome Craniosynostosis Radial Aplasia Syndrome
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Muenke Syndrome	Muenke Nonsyndromic Coronal Craniosynostosis Fgfr3-Related Craniosynostosis Fgfr3-Associated Coronal Synostosis Coronal Craniosynostosis MNKES Syndrome Of Coronal Craniosynostosis MNKS Fgfr3-Related Isolated Coronal Synostosis Muenke Non-Syndromic Coronal Craniosynostosis
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Blepharophimosis
Parietal Foramina	Enlarged Parietal Foramina Hereditary Cranium Bifidum Symmetric Parietal Foramina Catlin Marks Foramina Parietalia Permagna Caitlin Marks Cranium Bifidum Cranium Bifidum Occultum Fenestrae Parietals Symmetricae Fpp Giant Parietal Foramina Pfm Fenestrae Parietales Symmetricae Foramina, Parietal
Dysostosis	Dysostoses
Intracranial Hypertension	Raised Intracranial Pressure
Hypertelorism	Eyes Wide Apart Eyes Widely Set Hypertelorism Of Orbit Ocular Hypertelorism Orbital Separation Excessive
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Apert Syndrome	Acrocephalosyndactyly Type I Acs1 Acrocephalosyndactylia Acrocephalosyndactyly Acs I Apert-Crouzon Disease Acrocephalosyndactyly Type 1 Acrocephalosyndactyly, Type I Acs 1 Acrocephalo-Syndactyly Type 1 Syndactylic Oxycephaly Apert'S Syndrome Type I Acrocephalosyndactyly APRS
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Hepatitis D	Delta Hepatitis Hepatitis Delta Hdv Hepatitis D Virus Hepatitis D Infection
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Crouzon Syndrome	Crouzon Craniofacial Dysostosis Craniofacial Dysostosis Cfd1 Craniofacial Dysostosis Type 1 Crouzon Disease Crouzon'S Disease Craniofacial Dysostosis, Type I Craniofacial Dysarthrosis Craniofacial Dysostosis Syndrome CS Craniofacial Dysostosis Type I Vogt Cephalosyndactyly
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Bone Development Disease
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Hypertelorism, Microtia, Facial Clefting Syndrome	Hmc Syndrome Bixler Christian Gorlin Syndrome Bixler-Christian-Gorlin Syndrome Hypertelorism-Microtia-Facial Clefting Syndrome Bixler Syndrome Hypertelorism-Microtia-Clefting Syndrome Hypertelorism Microtia Facial Clefting Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Carpenter Syndrome 1	Carpenter Syndrome Acrocephalopolysyndactyly Type Ii Acps Ii CRPT1 Acrocephalopolysyndactyly Type 2 Acrocephalosyndactyly, Type Ii Acrocephalopolysyndactyly 2 Acps2 Acps 2 Type Ii Acrocephalosyndactyly Carpenter Syndrome, Type 1 Apert-Crouzon Disease
Jackson-Weiss Syndrome	JWS Craniosynostosis, Midfacial Hypoplasia, And Foot Abnormalities Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities Syndrome Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2013	Aristolactam I		99.44%	Unkown
HY-RS15281	TWIST1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179340	Antiproliferative agent-74	Inducer	/	Unkown
HY-179452	KRAS G13D-IN-2	Inhibitor	/	Unkown
HY-182069	CDK9-IN-47		/	Unkown
HY-RS20201	Twist1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26705	Twist1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TWIST1	VGNC	VGNC:36525
Felis catus	TWIST1	VGNC	VGNC:80750
Rattus norvegicus	TWIST1	RGD	RGD:621455
Mus musculus	TWIST1	MGD	MGI:98872
Others	TWIST1	NCBI