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ETS2 - ETS proto-oncogene 2, transcription factor Gene

Also Known as ETS2IT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2114

About ETS2

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:38,805,183-38,824,955 (from NCBI)

This gene has 9 transcripts (splice variants), 155 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues.

Summary

This gene encodes a transcription factor which regulates genes involved in development and Apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of Telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

ETS2 Products (2)

mRNA	Protein	Name
NM_001256295.2	NP_001243224.1	protein C-ets-2 isoform 2
NM_005239.6	NP_005230.1	protein C-ets-2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12637547	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12637547	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	11909962	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11909962	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18242510	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11583620	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12637547	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11909962	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETS2 Protein Structure

SAM_PNT

Ets

0
100
200
300
400
469 a.a.

Protein Preferred Names	Protein Names
protein C-ets-2	oncogene ETS-2

ETS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ETS2	P15036	COP1	Homo sapiens	Q8NHY2	Anti Tag CoIP	25117710
Intra	ETS2	P15036	COP1	Homo sapiens	Q8NHY2	Anti Tag CoIP	26496610
Intra	ETS2	P15036	CDK10	Homo sapiens	Q15131	Anti Bait CoIP	18242510
Intra	ETS2	P15036	CDK10	Homo sapiens	Q15131	Anti Tag CoIP	18242510
Intra	ETS2	P15036	TWIST1	Homo sapiens	Q15672	Anti Bait CoIP	18598946
Intra	ETS2	P15036	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	ETS2	P15036	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	ETS2	P15036	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	ETS2	P15036	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	ETS2	P15036	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	ETS2	P15036	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	ETS2	P15036	TP53	Homo sapiens	P04637	Anti Bait CoIP	26331536
Intra	ETS2	P15036	TP53	Homo sapiens	P04637	Pull Down	26331536
Intra	ETS2	P15036	TP53	Homo sapiens	P04637	Anti Tag CoIP	26331536
Intra	ETS2	P15036	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
Intra	ETS2	P15036	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
Intra	ETS2	P15036	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Choriocarcinoma	Chorioepithelioma
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Endometrium Carcinoma In Situ	Carcinoma In Situ Of Endometrium Endometrial Carcinoma In Situ
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Hyperhidrosis, Gustatory	Frey Syndrome Gustatory Sweating Auriculotemporal Nerve Syndrome Gustatory Hyperhidrosis Frey'S Syndrome Sweating, Gustatory HYPRG Baillarger Syndrome Hyperhidrosis Gustatory Auriculotemporal Syndrome
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Chromosomal Duplication Syndrome
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04563	ETS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20275	Ets2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26783	Ets2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ETS2	MGD	MGI:95456
Felis catus	ETS2	VGNC	VGNC:61981
Canis familiaris	ETS2	VGNC	VGNC:40495
Rattus norvegicus	ETS2	RGD	RGD:1584977
Macaca mulatta	ETS2	VGNC	VGNC:72440
Bos taurus	ETS2	VGNC	VGNC:28627
Others	ETS2	NCBI