1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. TC-S 7009

TC-S 7009 

Cat. No.: HY-18371
Handling Instructions

TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression.

For research use only. We do not sell to patients.

TC-S 7009 Chemical Structure

TC-S 7009 Chemical Structure

CAS No. : 1422955-31-4

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Description

TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2].

IC50 & Target

Kd: 81 nM (HIF-2α)[1]

In Vitro

TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment shows greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions[2].
TC-S 7009 (50 μM) treatment almost completely inhibits the hypoxia-induced NFATc2 nuclear translocation[2].

Cell Proliferation Assay[2]

Cell Line: HPF cells in hypoxic conditions
Concentration: 0-100 µM
Incubation Time: 72 hours
Result: Showed greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions.
Molecular Weight

308.65

Formula

C₁₂H₆ClFN₄O₃

CAS No.

1422955-31-4

SMILES

ClC1=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=CC(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TC-S 7009HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHIF-2αNFATIdiopathicpulmonaryfibrosisproliferationhypoxiaheterodimerizationDNA-bindingInhibitorinhibitorinhibit

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TC-S 7009
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