1422955-31-4
1422955-31-4
Chemical Structure
TC-S 7009
- CAS No.: 1422955-31-4
- Formula:C12H6ClFN4O3
- Molecular Weight:308.65
IUPAC Name: N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine
InChIKey: CDQUJZKBRAFWNG-UHFFFAOYSA-N
SMILES: ClC1=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=CC(F)=C1
Biological Activity: TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ? 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC-S 7009 | 99.81% | TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ? 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-18370HIF-2α-IN-3 -
Similarity Score 0.64
HY-125978JY-3-094 -
Similarity Score 0.61
HY-15907BBD -
Similarity Score 0.59
HY-141667MBD -
Similarity Score 0.59
HY-W2734134-Hydrazino-7-nitro-benzofurazan hydrazine adduct -
Similarity Score 0.57
HY-124013NBDA -
Similarity Score 0.57
HY-148611NSC339614 potassium -
Similarity Score 0.56
HY-Z6413Dacomitinib impurity 16 -
Similarity Score 0.56
HY-101084RNSC 228155 (Standard) -
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References
- [1]. Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013 Apr;9(4):271-6. [Content Brief]
- [2]. Senavirathna LK, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018 Feb 9;8(1):2709. [Content Brief]
