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Phospho-KIF22 (Ser427) Antibody (YA2498)

(Synonyms: KIF22; KID; KNSL4; Kinesin-like protein KIF22; Kinesin-like DNA-binding protein; Kinesin-like protein 4)

Phospho-KIF22 (Ser427) Antibody (YA2498) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-KIF22 (Ser427).

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • Phospho-KIF22 (Ser427) Antibody (YA2498) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

Phospho-KIF22 (Ser427) Antibody (YA2498) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-KIF22 (Ser427).

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 73 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 73 kDa
Species Reactivity Database

Entrez Gene: 3835 Human

SwissProt: Q14807 Human

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser427 of human KIF22 aa421-434.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Phosphorylated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    KIF22 is a Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells[1].

  • Subcellular Localization

    Nucleus; Cytoplasm, cytoskeleton

  • Expression


    Tissue_specificity:It is expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.

  • Isoforms & Post-Translational Modification

    Q14807 has 2 isomers: Q14807-1: 73262 Da (predicted); Q14807-2: 66307 Da (predicted).
    Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation

  • Subunit

    Interacts with FAM83D (PubMed:18485706). Interacts with SIAH1 (PubMed:11146551)

  • SwissProt ID

    Q14807

  • Gene ID
    3835 [NCBI]
  • Synonyms

    KIF22; KID; KNSL4; Kinesin-like protein KIF22; Kinesin-like DNA-binding protein; Kinesin-like protein 4

  • Research Field

    Signal Transduction

References

[1]. Iemura K, et al. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. Nat Commun. 2015 Mar 6;6:6447. [Content Brief]

Phospho-KIF22 (Ser427) Antibody (YA2498) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Phospho-KIF22 (Ser427) Antibody (YA2498) Product Image