Bruceantinol 

Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper^[1]. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc^[2].

IC₅₀: 2.4 pM (STAT3 DNA-binding ability)^[2]

606.61

Solid

C₃₀H₃₈O₁₃

53729-52-5

COC([[email protected]]12[[email protected]@]3([H])[[email protected]@]4(CO2)[[email protected]@]([[email protected]]([[email protected]@H]1O)O)([H])[[email protected]@]5([[email protected]@](C(C)=C(C(C5)=O)O)([H])C[[email protected]@]4([H])OC([[email protected]@H]3OC(/C=C(C)/C(C)(C)OC(C)=O)=O)=O)C)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Seung Mok Ryu, et al. Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper. Virus Res. 2017 Jan 2;227:49-56.  [Content Brief]

  [2]. Ning Wei, et al. Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. Oncogene. 2019 Mar;38(10):1676-1687.  [Content Brief]