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DNA2 inhibitor C5 

Cat. No.: HY-128729 Purity: 98.01%
Handling Instructions

DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress.

For research use only. We do not sell to patients.

DNA2 inhibitor C5 Chemical Structure

DNA2 inhibitor C5 Chemical Structure

CAS No. : 35973-25-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 129 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].

IC50 & Target

IC50: 20 μM (DNA2 nuclease)[1]

Molecular Weight

234.17

Formula

C₁₀H₆N₂O₅

CAS No.

35973-25-2

SMILES

O=C(C1=C(O)C2=CC=CC([N+]([O-])=O)=C2N=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (133.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2704 mL 21.3520 mL 42.7040 mL
5 mM 0.8541 mL 4.2704 mL 8.5408 mL
10 mM 0.4270 mL 2.1352 mL 4.2704 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

DNA2 inhibitor C5OthersInhibitorinhibitorinhibit

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Product name:
DNA2 inhibitor C5
Cat. No.:
HY-128729
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