Centanamycin
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening.
For research use only. We do not sell to patients.
- CAS No.: 413577-16-9
- Formula: C24H24ClN3O4
- Molecular Weight:453.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
0.045 μM
Compound: 11a
|
The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%
The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%
|
[PMID: 15916443] |
| L1210 | IC50 |
0.18 μM
Compound: 11a
|
The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%
The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%
|
[PMID: 15916443] |
| L1210 | IC50 |
55 nM
Compound: 6
|
Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
|
[PMID: 20579889] |
| P815 | IC50 |
0.068 μM
Compound: 11a
|
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
|
[PMID: 15916443] |
| P815 | IC50 |
0.068 μM
Compound: 4, CBI-TMI
|
Cytotoxicity against mouse P815 cells after 3 days
Cytotoxicity against mouse P815 cells after 3 days
|
[PMID: 16919946] |
Chemical Information
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CAS No. 413577-16-9
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Molecular Weight 453.92
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Formula C24H24ClN3O4
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SMILES
O=C(C1=CC2=C(N1)C(OC)=C(OC)C(OC)=C2)NC3=C(CCCl)C4=C(C=CC=C4)C(N)=C3
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Synonyms
ML-970; AS-I-145; NSC 716970
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)