GSD-11 

Cat. No.: HY-146738
Handling Instructions

GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer.

For research use only. We do not sell to patients.

GSD-11 Chemical Structure

GSD-11 Chemical Structure

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Description

GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].

In Vitro

GSD-11 (0,1, 10, 100, 1000 µM) shows potent cytotoxicity against PANC-1 cells with PC50 value of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM)[1].
GSD-11 (10 µM, 24 h) induces morphological change in PANC-1 cells[1].
GSD-11 (3, 5 µM, 24 h) inhibits the migration of PANC-1 tumor cells[1].
GSD-11 (1, 3, 5 µM, 24 h) shows strong colony formation inhibitory effect in PANC-1 tumor cells[1].
GSD-11 (2.5, 5, 10 µM) inhibits the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: PANC-1 cells
Concentration: 0,1, 10, 100, 1000 µM
Incubation Time:
Result: Showed preferential cytotoxicity against PANC-1 cells with PC50 of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM).

Western Blot Analysis[1]

Cell Line: PANC-1 cells
Concentration: 2.5, 5, 10 µM
Incubation Time:
Result: Inhibited the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions.
Molecular Weight

300.44

Formula

C20H28O2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GSD-11
Cat. No.:
HY-146738
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