2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. GAC0003A4

GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies.

For research use only. We do not sell to patients.

GAC0003A4 Chemical Structure

GAC0003A4 Chemical Structure

CAS No. : 929492-71-7

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5 mg USD 290 In-stock
10 mg USD 460 In-stock
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Based on 1 publication(s) in Google Scholar

GAC0003A4 Related Antibodies

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Description

GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies[1].

Molecular Weight

340.42

Formula

C20H24N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C2=C(C)C=CC=C2)C3=CC(OC)=CC(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (367.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9375 mL 14.6877 mL 29.3755 mL
5 mM 0.5875 mL 2.9375 mL 5.8751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9375 mL 14.6877 mL 29.3755 mL 73.4387 mL
5 mM 0.5875 mL 2.9375 mL 5.8751 mL 14.6877 mL
10 mM 0.2938 mL 1.4688 mL 2.9375 mL 7.3439 mL
15 mM 0.1958 mL 0.9792 mL 1.9584 mL 4.8959 mL
20 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6719 mL
25 mM 0.1175 mL 0.5875 mL 1.1750 mL 2.9375 mL
30 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
40 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
60 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
80 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
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GAC0003A4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GAC0003A4929492-71-7LXRLiver X receptorPDACMia-PaCa2PANC1Bx-PC3cancetumorInhibitorinhibitorinhibit

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