Farnesyl thiosalicylic acid amide
Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1092521-74-8
- Formula: C22H31NOS
- Molecular Weight:357.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | EC50 |
>20 μM
Compound: FTSA
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Cytotoxicity against human BxPC3 cells after 48 hrs by fluorescence assay
Cytotoxicity against human BxPC3 cells after 48 hrs by fluorescence assay
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[PMID: 24852279] |
| MIA PaCa-2 | EC50 |
>20 μM
Compound: FTSA
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Cytotoxicity against human MIAPaCa2 cells harboring K-Ras mutant oncogene after 48 hrs by fluorescence assay
Cytotoxicity against human MIAPaCa2 cells harboring K-Ras mutant oncogene after 48 hrs by fluorescence assay
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[PMID: 24852279] |
| PANC-1 | IC50 |
20 μM
Compound: FTS-A
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Cytotoxicity against human PANC1 cells after 5 to 7 days
Cytotoxicity against human PANC1 cells after 5 to 7 days
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[PMID: 19072665] |
| U-87MG ATCC | IC50 |
10 μM
Compound: FTS-A
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Cytotoxicity against human U87 cells after 5 to 7 days
Cytotoxicity against human U87 cells after 5 to 7 days
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[PMID: 19072665] |
Farnesyl thiosalicylic acid amide (50 μM, 24 h) decreases the levels of total Ras-GTP and K-Ras-GTP in Panc-1 and U87 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87 cells
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Concentration:50 μM
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Incubation Time:24 h
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Result:Reduced the level of N-Ras-GTP, phospho-ERK and phospho-AKT.
Farnesyl thiosalicylic acid amide (100 mg/kg, p.o., twice a day, 14 days) inhibits tumor growth in U87 nude mouse model[1].
Pharmacokinetic Analysis in Panc-1 Nude Mouse Model[1]
| Route | Dose (mg/kg) | half-life (min) | Tmax (h) | Cmax (ng/mL) | AUC0-inf (min*ng/mL) |
| i.g. | 100 | 314 | 110 | 371 | 108783 |