Misonidazole
Misonidazole (Ro 7-0582; SR 1354) is a hypoxic tumor cell radiosensitizer. Misonidazole also has antimicrobial effects.
For research use only. We do not sell to patients.
- CAS No.: 13551-87-6
- Formula: C7H11N3O4
- Molecular Weight:201.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-AA8 | IC50 |
12 mM
Compound: 1
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Aerobic growth inhibition in Chinese hamster cell line AA8
Aerobic growth inhibition in Chinese hamster cell line AA8
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[PMID: 7783125] |
| CHO-AA8 | IC50 |
12.1 mM
Compound: 1
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Concentration required to reduce AA8 cell numbers to 50% of controls in a growth inhibition microassay
Concentration required to reduce AA8 cell numbers to 50% of controls in a growth inhibition microassay
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[PMID: 8308864] |
| CHO-AA8 | IC50 |
12080 μM
Compound: 1 (misonidazole)
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Growth inhibition in CHO subline AA8 cells exposed for 18 hr under aerobic(air) conditions
Growth inhibition in CHO subline AA8 cells exposed for 18 hr under aerobic(air) conditions
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[PMID: 1479583] |
| HCT-116 | IC50 |
0.53 mM
Compound: 1
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Cytotoxicity against human HCT116 cells incubated for 4 hrs under anaerobic condition measured after 5 days by sulforhodamine B assay
Cytotoxicity against human HCT116 cells incubated for 4 hrs under anaerobic condition measured after 5 days by sulforhodamine B assay
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[PMID: 29253343] |
Chemical Information
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CAS No. 13551-87-6
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Appearance Solid
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Molecular Weight 201.18
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Formula C7H11N3O4
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Color Off-white to yellow
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SMILES
COCC(O)CN1C([N+]([O-])=O)=NC=C1
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Synonyms
Ro 7-0582; SR 1354
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Bibo Li, et al. Preparation, Characterization, and In Vitro pH-sensitivity Evaluation of Superparamagnetic Iron Oxide Nanoparticle- Misonidazole pH-sensitive Liposomes. Curr Drug Deliv. 2019;16(3):254-267. [Content Brief]
[2]. R C Knight, et al. Mechanism of action of nitroimidazole antimicrobial and antitumour radiosensitizing drugs. Effects of reduced misonidazole on DNA. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Oct;36(4):367-77. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Misonidazole Related Classifications
HY-105061 Related Classifications
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