CPF-7  (Synonyms: Caerulein precursor fragment)

CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes^[1][2].

CPF-7 (50 nM; 7 days) converts PANC-1 exocrine cells into pancreatic endocrine precursor cells^[1].
CPF-7 (3 µM; 20 min) produces the stimulation of insulin release in BRIN-BD11 rat clonal β-cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2586.00

C₁₁₈H₁₉₃N₃₃O₃₂

103238-06-8

Gly-Phe-Gly-Ser-Phe-Leu-Gly-Lys-Ala-Leu-Lys-Ala-Ala-Leu-Lys-Ile-Gly-Ala-Asn-Ala-Leu-Gly-Gly-Ala-Pro-Gln-Gln

GFGSFLGKALKAALKIGANALGGAPQQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Heydari M, et al. Differentiation of PANC-1 ductal cells to β-like cells via cellular GABA modulation by Magainin and CPF-7 peptides. Biochem Biophys Res Commun. 2022 Feb 1;597:128-133.  [Content Brief]

  [2]. Srinivasan D, et al. Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. Biochimie. 2013 Feb;95(2):429-35.  [Content Brief]