103238-06-8
Chemical Structure
CPF-7
Synonym(s): Caerulein precursor fragment
- CAS No.: 103238-06-8
- Formula:C118H193N33O32
- Molecular Weight:2586.00
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(NCC(NCC(N[C@@H](C)C(N3[C@@H](CCC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes[1][2].
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CPF-7 | CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Heydari M, et al. Differentiation of PANC-1 ductal cells to β-like cells via cellular GABA modulation by Magainin and CPF-7 peptides. Biochem Biophys Res Commun. 2022 Feb 1;597:128-133. [Content Brief]
- [2]. Srinivasan D, et al. Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. Biochimie. 2013 Feb;95(2):429-35. [Content Brief]
