Antiproliferative agent-42 

Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC₅₀ value of 12.54 μM^[1].

Antiproliferative agent-42 (0-100 μM, 48 h) can inhibit Panc-1 and PC3 as well as MDA-MB-231 cell lines with IC₅₀ values of 12.5 μM, 17.7 μM, and 13.1 μM, respectively^[1].
Antiproliferative agent-42 (12.54 μM, 48 h) can induce sub-G1 phase arrest in Panc-1 cancer cells^[1].
Antiproliferative agent-42 (12.54 μM) turns down the protein lever of cleaved-caspase-3 and caspase-3 in Panc-1 cancer cells, while the protein lever of pro-caspase-3 retains unchanged in Panc-1 cancer cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

363.33

C₁₈H₁₃N₅O₄

3002404-74-9

O=C1NNC(C2=C1C(C3=CC([N+]([O-])=O)=CC=C3)=C4N2CCN5C4=CC=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lish A B,et al. Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3‑d]pyridazine-8(9H)‑one Derivatives as Potential Cytotoxic Agents [J].[2023-11-08].

  [2]. Barghi Lish, Azam, et al. "Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5, 6-dihydropyrrolo [2 ″, 1 ″: 3′, 4′] pyrazino [1′, 2′: 1, 5] pyrrolo [2, 3-d] pyridazine-8 (9 H)-one Derivatives as Potential Cytotoxic Agents." ACS Omega (2023).