1. Protein Tyrosine Kinase/RTK
  2. IGF-1R
  3. I-OMe-Tyrphostin AG 538

I-OMe-Tyrphostin AG 538 (Synonyms: I-OMe-AG 538)

Cat. No.: HY-135680
Handling Instructions

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM.

For research use only. We do not sell to patients.

I-OMe-Tyrphostin AG 538 Chemical Structure

I-OMe-Tyrphostin AG 538 Chemical Structure

CAS No. : 1094048-77-7

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Description

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM[1].

IC50 & Target

IC50: 1 µM (PI5P4Kα)[1]

In Vitro

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium[1].
I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk[1].

Cell Viability Assay[1]

Cell Line: PANC-1 cells
Concentration: 0.1, 1, 10, 1000 µM
Incubation Time: 24 hours
Result: Cytotoxic to PANC-1 cells in nutrient-deprived medium.

Western Blot Analysis[1]

Cell Line: PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min)
Concentration: 0.03, 0.3, 3 µM
Incubation Time: 1 hour
Result: Blocked phosphorylation of IGF-1R, Akt and Erk.
Molecular Weight

437.19

Formula

C₁₇H₁₂INO₅

CAS No.

1094048-77-7

SMILES

N#C/C(C(C1=CC=C(O)C(O)=C1)=O)=C\C2=CC(OC)=C(O)C(I)=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

I-OMe-Tyrphostin AG 538I-OMe-AG 538IGF-1RInsulin-like growth factor-1 receptorcytotoxic,nutrient-deprivedpancreaticcancercellstumor,inositollipidInhibitorinhibitorinhibit

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I-OMe-Tyrphostin AG 538
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HY-135680
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