1. Cell Cycle/DNA Damage
    Epigenetics
    Protein Tyrosine Kinase/RTK
  2. Aurora Kinase
    Bcr-Abl
    IGF-1R
    Src

XL228 

Cat. No.: HY-15749 Purity: 99.22%
Data Sheet SDS Handling Instructions

XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.

For research use only. We do not sell to patients.
XL228 Chemical Structure

XL228 Chemical Structure

CAS No. : 898280-07-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $143 In-stock
5 mg $130 In-stock
10 mg $180 In-stock
50 mg $500 In-stock
100 mg $750 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases. IC50 Value: 3 nM (Aurora A Kinase); 5 nM (Ki, Abl)[1] Target: IGF1R; Aurora A; multikinase in vitro: Approximately 30% of the lines demonstrated XL228 IC50 values of <100nM in viability assays, including many lines with characterized ALK or FGFR mutations or amplifications. Cell lines showing the highest level of response to XL228 were often sensitive to other Aurora, ALK or FGFR inhibitors as well. Sub-20nM activity was demonstrated against FGFR2 in a cellular kinase ELISA assay, and confirmed by immunoblot analysis. Potency against ALK in the cell kinase assay was lower (approximately200 nM) [2]. in vivo: Clinical trial: Study of XL-228 in Subjects With Chronic Myeloid Leukemia or Philadelphia-Chromosome-Positive Acute Lymphocytic Leukemia. Phase 1

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00464113 Exelixis Chronic Myeloid Leukemia|Leukemia, Lymphoblastic, Acute, Philadelphia-Positive May 2007 Phase 1
NCT00526838 Exelixis Cancer|Lymphoma September 2007 Phase 1
View MoreCollapse
References
Molecular Weight

437.54

Formula

C₂₂H₃₁N₉O

CAS No.

898280-07-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
XL228
Cat. No.:
HY-15749
Quantity: