2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Robatumumab

Robatumumab  (Synonyms: Sch 717454; 19D12)

Cat. No.: HY-P99218 Purity: 99.90%
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Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research.

For research use only. We do not sell to patients.

Robatumumab Chemical Structure

Robatumumab Chemical Structure

CAS No. : 934235-44-6

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Description

Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research[1][2].

In Vitro

Robatumumab (0.02-80 nM; 0.5 or 4 h) downregulates IGF-IR and inhibits both basal and IGF-I-induced phosphorylation of IGF-IR and IRS-1 in SK-N-FI cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Robatumumab Related Antibodies

Western Blot Analysis[2]

Cell Line: SK-N-FI cells
Concentration: 0.02-80 nM
Incubation Time: 0.5 or 4 hours
Result: Inhibited the IGF-I–stimulated phosphorylation of IGF-IR after treatment 0.5 h.
Resulted in both inhibition of IGF-IR phosphorylation and receptor downregulation after treatment 4 h.
Resulted in a dose-dependent inhibition of the IGF-I–stimulated IRS-1 phosphorylation.
In Vivo

Robatumumab (intravenous injection; 0.04 or 0.1 mg/mouse; twice weekly; 18 d) inhibits the SK-N-FI tumor growth in xenograft model[2].
Robatumumab (intravenous injection; 0.02-0.5 mg/mouse; twice weekly; 35 d) inhibits the osteosarcoma growth in xenograft model[2].
Robatumumab (intravenous injection; 0.1 or 0.5 mg/mouse; twice weekly; 14 d) inhibits the SJCRH30 and RD rhabdomyosarcoma cell growth in xenograft model[2].
Robatumumab (intravenous injection; 0.1 or 0.5 mg/mouse; twice weekly; 2 w) blocks effectively pediatric tumor cell proliferation in vivo[2].
Robatumumab (intravenous injection; 0.5 mg/mouse; once; day 11 post-inoculation) modulates the blood vessel formation via its antiangiogenesis effect[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice inoculated with SK-N-FI tumor cells[2]
Dosage: 0.04 or 0.1 mg/mouse
Administration: Intravenous injection; 0.04 or 0.1 mg/mouse; twice weekly; 18 days
Result: Inhibited the SK-N-FI xenograft tumor by 96% in the 0.04 mg dose group and resulted in 11% tumor regression in the 0.1 mg dose group.
Animal Model: Nude mice inoculated with SJSA-1 osteosarcoma[2]
Dosage: 0.02, 0.1 or 0.5 mg/mouse
Administration: Intravenous injection; 0.02, 0.1 or 0.5 mg/mouse; twice weekly; 35 days
Result: Inhibited the tumor growth by 71%, 82%, and 88% at 0.02, 0.1, and 0.5 mg, respectively, at day 14 after treatment.
Animal Model: Nude mice inoculated with SJCRH30 and RD rhabdomyosarcoma cells[2]
Dosage: 0.1 or 0.5 mg/mouse
Administration: Intravenous injection; 0.1 or 0.5 mg/mouse; twice weekly; 14 days
Result: Inhibited tumor growth by 39% and 58% at 0.1 and 0.5 mg dose, respectively, in the RD rhabdomyosarcoma model.
Inhibited tumor growth by 37% and 53% at 0.1 and 1 mg dose, respectively, in the SJCRH30 model.
Animal Model: Nude mice inoculated with SK-N-FI neuroblastoma and SJSA-1 osteosarcoma[2]
Dosage: 0.1 or 0.5 mg/mouse
Administration: Intravenous injection; 0.1 or 0.5 mg/mouse; twice weekly; 2 weeks
Result: Reduced the tumor Ki-67 staining by 38% and along with significant change in SK-N-FI neuroblastoma xenograft.
Reduced the staining of Ki-67 by 37% and 51% after 0.1 and 0.5 mg SCH 717454 treatment, respectively, in the SJSA-1 osteosarcoma xenograft.
Animal Model: Nude mice inoculated with SJSA-1 osteosarcoma[2]
Dosage: 0.5 mg/mouse
Administration: Intravenous injection; 0.5 mg/mouse; once; day 11 post-inoculation
Result: Reduced in the intensity of the fluorescent lectin staining by 74% at 0.5 mg dose, showing thinner blood vessels and reduced branches, compared with control IgG1.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Robatumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.90%

COA (291 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Robatumumab934235-44-6Sch 717454 19D12Sch717454Sch-717454IGF-1RInsulin-like growth factor-1 receptoranti-tumor activityanti-proliferative activityosteosarcomaEwing sarcomaSK-N-FI cellInhibitorinhibitorinhibit

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