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Picropodophyllin

(Synonyms: AXL1717; Picropodophyllotoxin; PPP)
30 Cited Publications
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Based on 30 publication(s) in Google Scholar

Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • CAS No.: 477-47-4
  • Formula: C22H22O8
  • Molecular Weight:414.41
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Picropodophyllin Chemical Structure
    Picropodophyllin Chemical Structure
  • Experimental Validation Results for Picropodophyllin
  • Experimental Validation Results for Picropodophyllin
  • Experimental Validation Results for Picropodophyllin
  • Experimental Validation Results for Picropodophyllin
  • Experimental Validation Results for Picropodophyllin
CAS No.: 477-47-4
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Picropodophyllin Chemical Structure
    Picropodophyllin Chemical Structure
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    Picropodophyllin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]

    Customer Validation
     Viable cell numbers and PUFA-PC ratio after treatment with LY294002 (iPI3K, 10 µM), picropodophyllin (iRTK, 10 µM), ipatasertib (iAkt, 10 µM), or fatostatin (iSREBP1, 20 µM) for 48 h.

  • 1/16

    Picropodophyllin purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2021 Jul;16(7):830-839. [Abstract]

    Customer Validation
     Animals bearing subcutaneous (s.c.) iKras tumors were treated with AXL1717 (Picropodophyllin; 15 mg/kg dissolved in 100 μL mixture of 10% DMSO and 90% olive oil, via i.p. injection for 8 hr, 1 day, or 4 days prior to nanoparticle injection (1, 2 , or 5 days prior to tissue harvesting)), and biodistribution was measured 24 hr later by fluorescent reflectance imaging.

  • 1/16

    Picropodophyllin purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2021 Jul;16(7):830-839. [Abstract]

    Customer Validation
     Mice bearing subcutaneous iKras tumors were treated with vehicle controls, nab-PTX, AXL1717 (Picropodophyllin; 15 mg/kg dissolved in 100 μL mixture of 10% DMSO and 90% olive oil, via i.p. injection for 8 hr, 1 day, or 4 days prior to nanoparticle injection (1, 2 , or 5 days prior to tissue harvesting)), simultaneous treatment of both (Co-tx), or sequential treatment of both (Sep-tx) with equal cumulative doses. Tumor volume and survival based on humane endpoint (f, n=4 per group, log-rank test) were monitored.

  • 1/16

    Picropodophyllin purchased from MedChemExpress. Usage Cited in: Cancer Sci. 2018 Apr;109(4):1166-1176. [Abstract]

    Customer Validation
     PPP downregulates IGF-1R as well as the total and phosphor-HER2 levels in the MKN7 cell line.

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    Picropodophyllin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2016 Feb;37(2):217-27. [Abstract]

    Customer Validation
     The phosphorylation of IGF-1R is observed by a Western blot assay after the cells are pretreated with PPP 50 nM or a diluent for 60 min and deprived of insulin for 5 min.

  • Picropodophyllin