SKI-349
Based on 1 publication(s) in Google Scholar
SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 727686-80-8
- Formula: C19H19N3O4S
- Molecular Weight:385.44
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SKI-349
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
10 nM
Compound: 5p
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Antiproliferative activity against human CEM cells after 2 days by coulter counter method
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
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[PMID: 19663386] |
| FM3A | IC50 |
71 nM
Compound: 5p
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Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
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[PMID: 19663386] |
| HeLa | IC50 |
52 nM
Compound: 5p
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Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
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[PMID: 19663386] |
| HL-60 | IC50 |
22 nM
Compound: SKI-349
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Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 32736077] |
| L1210 | IC50 |
38 nM
Compound: 5p
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Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
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[PMID: 19663386] |
| MOLT-4 | IC50 |
37 nM
Compound: 5p
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Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
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[PMID: 19663386] |
Chemical Information
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CAS No. 727686-80-8
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Appearance Solid
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Molecular Weight 385.44
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Formula C19H19N3O4S
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Color Light yellow to yellow
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SMILES
O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=C(C(OC)=C3)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 125 mg/mL (324.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hengst JA, et al. Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127453. [Content Brief]
[2]. Chen L, et al. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. Tohoku J Exp Med. 2023 Dec 21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5944 mL | 12.9722 mL | 25.9444 mL | 64.8609 mL |
| 5 mM | 0.5189 mL | 2.5944 mL | 5.1889 mL | 12.9722 mL | |
| 10 mM | 0.2594 mL | 1.2972 mL | 2.5944 mL | 6.4861 mL | |
| 15 mM | 0.1730 mL | 0.8648 mL | 1.7296 mL | 4.3241 mL | |
| 20 mM | 0.1297 mL | 0.6486 mL | 1.2972 mL | 3.2430 mL | |
| 25 mM | 0.1038 mL | 0.5189 mL | 1.0378 mL | 2.5944 mL | |
| 30 mM | 0.0865 mL | 0.4324 mL | 0.8648 mL | 2.1620 mL | |
| 40 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6215 mL | |
| 50 mM | 0.0519 mL | 0.2594 mL | 0.5189 mL | 1.2972 mL | |
| 60 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0810 mL | |
| 80 mM | 0.0324 mL | 0.1622 mL | 0.3243 mL | 0.8108 mL | |
| 100 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.6486 mL |
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